Journal Article

Cryotherapy in extra-abdominal desmoid tumors: A systematic review and meta-analysis

Ouellette, Hugue A., Munk, Peter L., Somasundaram, Nagavalli, Mallinson, Paul I., Vora, Bimal Mayur Kumar, Abdul Kadir, Hanis, Yan, Yet Yen, Tan, Tien Jin, Sheikh, Adnan

2021

Overview

Desmoid tumor is a locally-invasive neoplasm that causes significant morbidity. There is recent interest in cryotherapy for treatment of extra-abdominal desmoid tumors. This systematic review assesses evidence on safety and efficacy of cryotherapy in the treatment of extra-abdominal desmoid tumors. The systematic review was conducted with reference to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Literature search was performed using MEDLINE and the Cochrane Central Register of Controlled Trials. 9 full text papers were reviewed and meta-analysis was performed for measures of safety, efficacy and symptom relief. The estimated pooled proportion of major and minor complications was 4.2% (95% CI, 1.8-9.6; I 2 = 0%) and 10.2% (95% CI, 5.7-17.8; I 2 = 0%) respectively. The estimated pooled proportion of non-progressive disease rate of all studies was 85.8% (95% CI, 73.4-93.0; I 2 = 32.9%). The estimated progression free survival rate at 1 year was 84.5% (95% CI:74.6-95.8) and 78.0% at 3 years (95% CI: 63.8-95.3). As for pain control, the estimated pooled proportion of patients with decrease in visual analogue scale (VAS) > = 3 for those with VAS > = 3 before treatment for 2 studies was 87.5% (95% CI, 0.06-100; I 2 = 71.5%) while 37.5% to 96.9% of patients were reported to have experienced partial or complete symptom relief in the other studies. Cryotherapy is a safe and effective treatment modality for extra-abdominal desmoid tumors with efficacy similar to those treated with traditional strategies in the short to medium term.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Abdomen / Ablation / Anti-inflammatory agents / Bias / Cancer therapies / Care and treatment / Clinical trials / Cold / Complications / Cryotherapy / Cryotherapy - adverse effects / Cryotherapy - methods / Diagnosis / Fibromas / Fibromatosis, Aggressive - epidemiology / Fibromatosis, Aggressive - therapy / Health aspects / Hospitals / Humans / Literature reviews / Medicine and Health Sciences / Meta-analysis / Morbidity / Mutation / Pain / Patients / Progression-Free Survival / Research and Analysis Methods / Risk factors / Safety / Survival / Systematic review / Treatment Outcome / Tumors