Journal Article

HIV treatment response among female sex workers participating in a treatment as prevention demonstration project in Cotonou, Benin

Kania, Dramane, Geraldo, Nassirou, Affolabi, Dissou, Gangbo, Flore, Zannou, Marcel Djimon, Guédou, Fernand A., Kêkê, René Kpèmahouton, Alary, Michel, Béhanzin, Luc, Goma-Matsétsé, Ella, Diallo, Mamadou, Bachabi, Moussa, Diabaté, Souleymane

2020

Overview

Female sex workers (FSWs) play a key role in HIV transmission in West Africa, while they have limited access to antiretroviral therapy (ART). In line with UNAIDS recommendations extending ART to all HIV-infected individuals, we conducted this demonstration project on immediate treatment as prevention (TasP) among FSWs in Cotonou, Benin. We report data on treatment response and its relation to adherence, as well as on ART-resistant genotypes. Complete follow-up varied between 12 and 24 months. At each three-monthly visit, a questionnaire was administered, clinical examinations were carried out and blood samples collected. Adherence to treatment was estimated by self-report. Viral RNA was genotyped at baseline and final visits for drug resistance. Generalized estimating equations for repeated measures with a log-binomial link were used to analyze time trends and the association between adherence and virological response to treatment. One-hundred-seven HIV-positive and ART-naive FSWs were enrolled; 59.8% remained in the cohort till study completion and 62.6% had a final visit. Viral load<1000 (below quantification limit [<50]) was attained in 73.1% (64.6%) of participants at month-6, 84.8% (71.2%) at month-12, and 80.9% (65.1%) at the final visit. The proportion of women with suppressed (below quantification limit) viral load increased with increasing self-reported adherence (p = 0.06 (0.003), tests for trend). The proportion of participants with CD4≤500 also decreased drastically throughout follow-up (p < .0001). Twelve participants exhibited ART-resistant genotypes at baseline, but only two at their final visit. Our findings indicate that TasP is widely accepted among FSWs in Cotonou and could be implemented with relative success. However, due to mobility in this population, follow-up was sub-optimal, suggesting that large geographical coverage of FSW-friendly clinics is needed for sustained treatment implementation. We also fell short of the UNAIDS objective of 90% viral suppression among treated patients, underlining the need for better adherence support programs.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adolescent / Adult / AIDS treatment / Analysis / Anti-HIV Agents - therapeutic use / Antigens / Antiretroviral agents / Antiretroviral drugs / Antiretroviral therapy / Art exhibitions / Benin - epidemiology / Biology and Life Sciences / CD4 antigen / Disease transmission / Drug resistance / Drug Resistance, Viral / Efavirenz / Female / Females / Follow-Up Studies / Genotype / Genotypes / Highly active antiretroviral therapy / HIV / HIV Infections - drug therapy / HIV Infections - epidemiology / HIV Infections - prevention & control / HIV patients / HIV-1 - immunology / Human immunodeficiency virus / Humans / Laboratories / Lopinavir / Medical tests / Medicine and health sciences / Middle Aged / Patient Compliance / People and Places / Population / Prevention / Questionnaires / Ribonucleic acid / RNA / RNA, Viral - genetics / Self Report / Sex / Sex industry / Sex oriented businesses / Sex Workers / Sexually transmitted diseases / Social Sciences / STD / Syphilis / Treatment Outcome / Viral Load / Working women / Young Adult