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Pleiotrophin Commits Human Bone Marrow Mesenchymal Stromal Cells towards Hypertrophy during Chondrogenesis

by Rouard, Helene , Chevallier, Nathalie , Lebouvier, Angelique , Bouderlique, Thibault , Henault, Emilie , Courty, José , Frescaline, Guilhem , Bierling, Phillipe , Albanese, Patricia

in Alkaline phosphatase / Biocompatibility / Bioengineering / Biology / Biomedical materials / Bone growth / Bone healing / Bone marrow / Bone Marrow Cells - cytology / Bone Marrow Cells - metabolism / Calcification / Callus / Carrier Proteins - metabolism / Cartilage / Cell Differentiation - physiology / Cell Enlargement / Chondrocytes / Chondrogenesis / Chondrogenesis - physiology / Collagen / Collagenase 3 / Cytokines - metabolism / Differentiation / Endochondral bone / Extracellular matrix / Gene expression / Genes / Growth factors / Growth plate / Healing / Humans / Hypertrophy / Kinases / Laboratories / Life Sciences / Lymphoma / Medical research / Medicine / Mesenchymal stem cells / Mesenchymal Stromal Cells - cytology / Mesenchymal Stromal Cells - metabolism / Mesenchyme / Osteoblastogenesis / Osteoblasts / Phosphatase / Phosphatases / Physiology / Pleiotrophin / Polymerase chain reaction / Proteins / Receptors / Regeneration / Regeneration (physiology) / Reverse transcription / Rodents / Signaling / Stem cells / Stromal cells / Studies / Transcription (Genetics) / Trauma

2014

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Pleiotrophin Commits Human Bone Marrow Mesenchymal Stromal Cells towards Hypertrophy during Chondrogenesis

by Rouard, Helene , Chevallier, Nathalie , Lebouvier, Angelique , Bouderlique, Thibault , Henault, Emilie , Courty, José , Frescaline, Guilhem , Bierling, Phillipe , Albanese, Patricia

2014

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Pleiotrophin Commits Human Bone Marrow Mesenchymal Stromal Cells towards Hypertrophy during Chondrogenesis

by Rouard, Helene , Chevallier, Nathalie , Lebouvier, Angelique , Bouderlique, Thibault , Henault, Emilie , Courty, José , Frescaline, Guilhem , Bierling, Phillipe , Albanese, Patricia

2014

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Journal Article

Pleiotrophin Commits Human Bone Marrow Mesenchymal Stromal Cells towards Hypertrophy during Chondrogenesis

Rouard, Helene,

Chevallier, Nathalie,

Lebouvier, Angelique,

Bouderlique, Thibault,

Henault, Emilie,

Courty, José,

Frescaline, Guilhem,

Bierling, Phillipe,

Albanese, Patricia

2014

Overview

Pleiotrophin (PTN) is a growth factor present in the extracellular matrix of the growth plate during bone development and in the callus during bone healing. Bone healing is a complicated process that recapitulates endochondral bone development and involves many cell types. Among those cells, mesenchymal stromal cells (MSC) are able to differentiate toward chondrogenic and osteoblastic lineages. We aimed to determine PTN effects on differentiation properties of human bone marrow stromal cells (hBMSC) under chondrogenic induction using histological analysis and quantitative reverse transcription polymerase chain reaction. PTN dramatically potentiated chondrogenic differentiation as indicated by a strong increase of collagen 2 protein, and cartilage-related gene expression. Moreover, PTN increased transcription of hypertrophic chondrocyte markers such as MMP13, collagen 10 and alkaline phosphatase and enhanced calcification and the content of collagen 10 protein. These effects are dependent on PTN receptors signaling and PI3 K pathway activation. These data suggest a new role of PTN in bone regeneration as an inducer of hypertrophy during chondrogenic differentiation of hBMSC.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Alkaline phosphatase

/ Biocompatibility

/ Bioengineering

/ Biology

/ Biomedical materials

/ Bone growth

/ Bone healing