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Pathway paradigms revealed from the genetics of inflammatory bowel disease
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Pathway paradigms revealed from the genetics of inflammatory bowel disease
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Journal Article
Pathway paradigms revealed from the genetics of inflammatory bowel disease
2020
Overview
Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and amplified by the confluence of multiple genetic and environmental variables that perturb the immune–microbiome axis. The challenge of dissecting pathological mechanisms underlying IBD has led to the development of transformative approaches in human genetics and functional genomics. Here we describe IBD as a model disease in the context of leveraging human genetics to dissect interactions in cellular and molecular pathways that regulate homeostasis of the mucosal immune system. Finally, we synthesize emerging insights from multiple experimental approaches into pathway paradigms and discuss future prospects for disease-subtype classification and therapeutic intervention.
This Review examines inflammatory bowel disease in the context of human genetics studies that help to identify pathways that regulate homeostasis of the mucosal immune system and discusses future prospects for disease-subtype classification and therapeutic intervention.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Genetic Predisposition to Disease
/ Genetics
/ Genomes
/ Genomics
/ Humanities and Social Sciences
/ Humans
/ Immunity, Mucosal - genetics
/ Immunity, Mucosal - immunology
/ Inflammatory Bowel Diseases - genetics
/ Inflammatory Bowel Diseases - immunology
/ Inflammatory Bowel Diseases - pathology
/ Inflammatory Bowel Diseases - therapy
/ Intestinal Mucosa - immunology
/ Intestinal Mucosa - microbiology
/ Review
/ Science
