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Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial
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Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial
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Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial
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Journal Article
Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial
2017
Overview
Background
We conducted an ancillary study among individuals who had participated in a cluster-randomized PCV-7 trial in rural Gambia (some clusters were wholly-vaccinated while in others only young children had been vaccinated), to determine the prevalence and risk factors for
Staphylococcus aureus
nasopharyngeal carriage.
Methods
Two hundred thirty-two children aged 5–10 years were recruited and followed from 4 to 20 months after vaccination started. We collected 1264 nasopharyngeal swabs (NPS).
S. aureus
was isolated following conventional microbiological methods. Risk factors for carriage were assessed by logistic regression.
Results
Prevalence of
S. aureus
carriage was 25.9%. In the univariable analysis, prevalence of
S. aureus
carriage was higher among children living in villages wholly-vaccinated with PCV-7 [OR = 1.57 95%CI (1.14 to 2.15)] and children with least 1 year of education [OR = 1.44 95%CI (1.07 to 1.92)].
S. aureus
carriage was also higher during the rainy season [OR = 1.59 95%CI (1.20 to 2.11)]. Carriage of
S. pneumoniae
did not have any effect on
S. aureus
carriage for any pneumococcal, vaccine-type (VT) or non-vaccine-type (NVT) carriage. Multivariate analysis showed that the higher prevalence of
S. aureus
observed among children living in villages wholly-vaccinated with PCV-7 occurred only during the rainy season OR 2.72 95%CI (1.61–4.60) and not in the dry season OR 1.28 95%CI (0.78–2.09).
Conclusions
Prevalence of nasopharyngeal carriage of
S. aureus
among Gambian children increased during the rainy season among those children living in PCV-7 wholly vaccinated communities. However, carriage of
S. aureus
is not associated with carriage of
S. pneumoniae
.
Trial registration
ISRCTN51695599
. Registered August 04th 2006.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Analysis
/ Bacteria
/ Carrier State - microbiology
/ Child
/ Children
/ Female
/ Heptavalent Pneumococcal Conjugate Vaccine - therapeutic use
/ Humans
/ Male
/ Medicine
/ PCV
/ Pneumococcal Vaccines - therapeutic use
/ Rain
/ Seasons
/ Sepsis
/ Staphylococcal Infections - epidemiology
/ Staphylococcal Infections - microbiology
/ Staphylococcus aureus - isolation & purification
/ Staphylococcus aureus - pathogenicity
/ Staphylococcus aureus infections
/ Streptococcus pneumoniae - isolation & purification
/ Streptococcus pneumoniae - pathogenicity
/ Studies
/ Towns
/ Vaccines
