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The effect of antimicrobial drug use on the composition of the genitourinary microbiota in an elderly population
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The effect of antimicrobial drug use on the composition of the genitourinary microbiota in an elderly population
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The effect of antimicrobial drug use on the composition of the genitourinary microbiota in an elderly population
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Journal Article
The effect of antimicrobial drug use on the composition of the genitourinary microbiota in an elderly population
2019
Overview
Background
The urinary tract is inhabited by a diversity of microorganisms, known as the genitourinary microbiota. Here, we investigated the association between the use of antimicrobial drugs and the composition of the genitourinary microbiota.
Results
Clean-catch urinary samples were collected from 27 participants of the Rotterdam Study. Bacterial DNA was extracted and the 16S ribosomal RNA gene variable regions V3 and V4 were analyzed using Illumina sequencing. 23 of the 27 participants were included in the analysis. The population consisted of 10 men and 13 women with a mean age of 75 ± 3 years. The time between the last prescription of an antimicrobial drug and sampling was determined and categorized. The use of antimicrobial drugs prior to urine sampling was associated with statistically significant differences in the beta-diversity of the genitourinary microbiota. No association was found between antimicrobial drug use and the alpha-diversity of the genitourinary microbiota. Operational Taxonomic Units (OTUs) that were lowest in participants who used antimicrobial drug belonged to
Lactobacillus
and
Finegoldia.
In contrast, an OTU belonging to the genus
Parabacteroides
had higher abundances. Also, an OTU belonging to the species
E
.
coli
was higher in the participants who used antimicrobial drugs.
Conclusion
Prior use of antimicrobial drugs is associated with a different composition of the genitourinary microbiota. Our results might indicate a persisting effect of antimicrobial drugs on the composition of the microbiota, but reverse causality cannot be ruled out. Future studies are needed to differentiate between two possibilities. Genitourinary dysbiosis could be the result of antimicrobial drug use or genitourinary dysbiosis could be a risk factor for urinary tract infections resulting in increased use of antimicrobial drugs. This may have important implications for treatment and prevention of (recurrent) UTIs.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Aged
/ Anti-Infective Agents - adverse effects
/ Anti-Infective Agents - pharmacology
/ Anti-Infective Agents - therapeutic use
/ Antiinfectives and antibacterials
/ Biomedical and Life Sciences
/ Clinical microbiology and vaccines
/ Diabetes
/ DNA
/ Drug use
/ Drugs
/ Dysbiosis - chemically induced
/ E coli
/ Elderly
/ Female
/ Females
/ Genes
/ Humans
/ Male
/ Microbiota (Symbiotic organisms)
/ Mycology
/ RNA
/ RNA, Ribosomal, 16S - genetics
/ rRNA 16S
/ Sampling
/ Studies
/ Urinary Tract - microbiology
/ Urinary Tract Infections - etiology
/ Urinary Tract Infections - microbiology
/ Urine
/ Virology
