Journal Article

Antioxidant and antibacterial potential of bioactive extraction from Cadaba glandulosa leaves

Sabei, Fahad Y., Rehman, Zia ur, Elmobark, Mohamed Eltaib, Salawi, Ahmad, Ahmad, Sarfaraz, Ali, Maksood, Moni, Sivakumar S., Hadi, Ibrahim Mohammed, Moshi, Jobran M., Alsabei, Hanan M., Dawod, Ogail Yousif

2026

Overview

This study investigated the bioactive components and explored the antioxidant and antibacterial properties of the methanolic leaf extracts of Cadaba glandulosa (MLCG). The observed activity is related to the diverse chemical composition of the extract as determined by gas chromatography-mass spectrometry (GC-MS) analysis, which tentatively identified 18 distinct compounds. Notable compounds include methyl dodecanoate, methyl tetradecanoate, 9,12-octadecadienoyl chloride, hexadecanoic acid methyl ester, palmitoleic acid, anethole, brefeldin A and oleic acid. The antioxidant tests showed a significant scavenging activity of 88.2% at a concentration of 381.5 µg/mL, which underlines the effectiveness of the extract in neutralizing free radicals. The total phenolic content in MLCG was found to be 79.5%, corresponding to 250.8 mg of gallic acid equivalents (GAE)/ mL.The antibacterial activity of MLCG showed variability between bacterial strains, with the strongest inhibition observed against Staphylococcus aureus and Streptococcus pyogenes , both Gram-positive bacteria. The extract showed moderate activity against Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa , while the least activity was observed against Klebsiella pneumoniae . In this study, the impressive antioxidant and antibacterial properties of MLCG underline the therapeutic potential of Cadaba glandulosa as a natural source of antioxidant and antibacterial agents.

• Publisher: Public Library of Science,PLOS,Public Library of Science (PLoS)
• Subject: Acids / Analysis / Anethole / Angiosperms / Anti-Bacterial Agents - chemistry / Anti-Bacterial Agents - isolation & purification / Anti-Bacterial Agents - pharmacology / Antibacterial activity / Antibacterial agents / Antimicrobial agents / Antioxidants / Antioxidants - chemistry / Antioxidants - isolation & purification / Antioxidants - pharmacology / Bacteria / Bacterial infections / Biological activity / Biology and Life Sciences / Brefeldin A / Cadaba / Calibration / Care and treatment / Chemical composition / Chemical properties / Chromatography / Coliforms / E coli / Free radicals / Gallic acid / Gas chromatography / Gas Chromatography-Mass Spectrometry / Gram-negative bacteria / Gram-positive bacteria / Klebsiella / Mass spectrometry / Mass spectroscopy / Medicine and Health Sciences / Microbial Sensitivity Tests / Monounsaturated fatty acids / Oleic acid / Palmitic acid / Palmitoleic acid / Phenolic compounds / Phenols / Physical Sciences / Plant extracts / Plant Extracts - chemistry / Plant Extracts - pharmacology / Plant Leaves - chemistry / Research and Analysis Methods / Saturated fatty acids / Scavenging / Scientific imaging / Solvents / Staphylococcus aureus - drug effects / Streptococcus pyogenes - drug effects / Temperature