Journal Article

Factors associated with survival of patients with solid Cancer alive after intensive care unit discharge between 2005 and 2013

Gheerbrant, Hubert, Terzi, Nicolas, Timsit, Jean-François, Toffart, Anne-Claire, Laramas, Mathieu, Jacquet, Emmanuelle, Falque, Loic, Levra, Matteo Giaj, Moro-Sibilot, Denis, Ruckly, Stéphane

2021

Overview

Background At intensive care unit (ICU) admission, the issue about prognosis of critically ill cancer patients is of clinical interest, especially after ICU discharge. Our objective was to assess the factors associated with 3- and 6-month survival of ICU cancer survivors. Methods Based on the French OutcomeRea™ database, we included solid cancer patients discharged alive, between December 2005 and November 2013, from the medical ICU of the university hospital in Grenoble, France. Patient characteristics and outcome at 3 and 6 months following ICU discharge were extracted from available database. Results Of the 361 cancer patients with unscheduled admissions, 253 (70%) were discharged alive from ICU. The main primary cancer sites were digestive (31%) and thoracic (26%). The 3- and 6-month mortality rates were 33 and 41%, respectively. Factors independently associated with 6-month mortality included ECOG performance status (ECOG-PS) of 3–4 (OR,3.74; 95%CI: 1.67–8.37), metastatic disease (OR,2.56; 95%CI: 1.34–4.90), admission for cancer progression (OR,2.31; 95%CI: 1.14–4.68), SAPS II of 45 to 58 (OR,4.19; 95%CI: 1.76–9.97), and treatment limitation decision at ICU admission (OR,4.00; 95%CI: 1.64–9.77). Interestingly, previous cancer chemotherapy prior to ICU admission was independently associated with lower 3-month mortality (OR, 0.38; 95%CI: 0.19–0.75). Among patients with an ECOG-PS 0–1 at admission, 70% ( n  = 66) and 61% ( n  = 57) displayed an ECOG-PS 0–2 at 3- and 6-months, respectively. At 3 months, 74 (55%) patients received anticancer treatment, 13 (8%) were given exclusive palliative care. Conclusions Factors associated with 6-month mortality are almost the same as those known to be associated with ICU mortality. We highlight that most patients recovered an ECOG-PS of 0–2 at 3 and 6 months, in particular those with a good ECOG-PS at ICU admission and could benefit from an anticancer treatment following ICU discharge.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Aged / Anticancer treatments / Antimitotic agents / Antineoplastic agents / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Biomedical and Life Sciences / Biomedicine / Cancer / cancer burden and supportive therapy / Cancer Research / Cancer survivors / Cancer therapies / Care and treatment / Chemotherapy / Diagnosis / Digestive system cancer / Disease / Female / Follow-Up Studies / France / Health Promotion and Disease Prevention / Hospital Mortality - trends / Hospitalization - statistics & numerical data / Hospitals / Humans / Intensive care / Intensive care unit / Intensive care units / Intensive Care Units - statistics & numerical data / Life Sciences / Male / Medical prognosis / Medicine/Public Health / Metastases / Metastasis / Middle Aged / Mortality / Neoplasms - drug therapy / Neoplasms - mortality / Neoplasms - pathology / Oncology / Patient admissions / Patient Discharge - statistics & numerical data / Patient outcomes / Patients / Performance status / Prognosis / Prospective Studies / Research Article / Retrospective Studies / Risk factors / Software / Solid cancer / Statistics / Surgical Oncology / Survival / Survival Rate / Survivorship / Thoracic cancer / Thorax / Time Factors