Asset Details
Do you wish to reserve the book?
A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction
Do you wish to request the book?
A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction
2021
Overview
Dengue virus causes approximately 96 million symptomatic infections annually, manifesting as dengue fever or occasionally as severe dengue
1
,
2
. There are no antiviral agents available to prevent or treat dengue. Here, we describe a highly potent dengue virus inhibitor (JNJ-A07) that exerts nanomolar to picomolar activity against a panel of 21 clinical isolates that represent the natural genetic diversity of known genotypes and serotypes. The molecule has a high barrier to resistance and prevents the formation of the viral replication complex by blocking the interaction between two viral proteins (NS3 and NS4B), thus revealing a previously undescribed mechanism of antiviral action. JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models. Delaying start of treatment until peak viraemia results in a rapid and significant reduction in viral load. An analogue is currently in further development.
The small molecule JNJ-A07 interferes with the interaction between the NS3 and NS4B proteins of dengue virus and reduces the viral load in mice even when first administered at peak viraemia.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/106
/ 38/109
/ 38/47
/ 38/70
/ 38/90
/ 64/110
/ 82/80
/ Animals
/ Antiviral Agents - pharmacokinetics
/ Antiviral Agents - pharmacology
/ Antiviral Agents - therapeutic use
/ Dengue
/ Dengue Virus - classification
/ Female
/ Fever
/ Humanities and Social Sciences
/ Male
/ Membrane Proteins - antagonists & inhibitors
/ Membrane Proteins - metabolism
/ Mice
/ Mutation
/ Protein-protein interactions
/ RNA Helicases - antagonists & inhibitors
/ Science
/ Serine Endopeptidases - metabolism
/ Viral Nonstructural Proteins - antagonists & inhibitors
/ Viral Nonstructural Proteins - metabolism
/ Viremia
/ Virus Replication - drug effects
/ Viruses
