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Research overview of L-DOPA production using a bacterial enzyme, tyrosine phenol-lyase
by
KUMAGAI, Hidehiko
, SUZUKI, Hideyuki
, KOYANAGI, Takashi
, KATAYAMA, Takane
in
Amino acids
/ Ammonia
/ Bacteria
/ Blood-brain barrier
/ Brain research
/ Dihydroxyphenylalanine
/ Dopamine
/ E coli
/ Enzymatic synthesis
/ Enzymes
/ Erwinia herbicola
/ Escherichia intermedia
/ Gene expression
/ Genes
/ Industrial production
/ Investigations
/ L-DOPA
/ Laboratories
/ Levodopa
/ Microorganisms
/ Movement disorders
/ Mutation
/ Neurodegenerative diseases
/ Parkinson's disease
/ Phenols
/ Proteins
/ Reaction mechanisms
/ Review
/ Strains (organisms)
/ Tpl gene
/ Tyrosine
/ Tyrosine phenol-lyase
/ Tyrosine Phenol-Lyase - genetics
/ Tyrosine Phenol-Lyase - metabolism
/ TyrR
2023
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Research overview of L-DOPA production using a bacterial enzyme, tyrosine phenol-lyase
by
KUMAGAI, Hidehiko
, SUZUKI, Hideyuki
, KOYANAGI, Takashi
, KATAYAMA, Takane
in
Amino acids
/ Ammonia
/ Bacteria
/ Blood-brain barrier
/ Brain research
/ Dihydroxyphenylalanine
/ Dopamine
/ E coli
/ Enzymatic synthesis
/ Enzymes
/ Erwinia herbicola
/ Escherichia intermedia
/ Gene expression
/ Genes
/ Industrial production
/ Investigations
/ L-DOPA
/ Laboratories
/ Levodopa
/ Microorganisms
/ Movement disorders
/ Mutation
/ Neurodegenerative diseases
/ Parkinson's disease
/ Phenols
/ Proteins
/ Reaction mechanisms
/ Review
/ Strains (organisms)
/ Tpl gene
/ Tyrosine
/ Tyrosine phenol-lyase
/ Tyrosine Phenol-Lyase - genetics
/ Tyrosine Phenol-Lyase - metabolism
/ TyrR
2023
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Research overview of L-DOPA production using a bacterial enzyme, tyrosine phenol-lyase
by
KUMAGAI, Hidehiko
, SUZUKI, Hideyuki
, KOYANAGI, Takashi
, KATAYAMA, Takane
in
Amino acids
/ Ammonia
/ Bacteria
/ Blood-brain barrier
/ Brain research
/ Dihydroxyphenylalanine
/ Dopamine
/ E coli
/ Enzymatic synthesis
/ Enzymes
/ Erwinia herbicola
/ Escherichia intermedia
/ Gene expression
/ Genes
/ Industrial production
/ Investigations
/ L-DOPA
/ Laboratories
/ Levodopa
/ Microorganisms
/ Movement disorders
/ Mutation
/ Neurodegenerative diseases
/ Parkinson's disease
/ Phenols
/ Proteins
/ Reaction mechanisms
/ Review
/ Strains (organisms)
/ Tpl gene
/ Tyrosine
/ Tyrosine phenol-lyase
/ Tyrosine Phenol-Lyase - genetics
/ Tyrosine Phenol-Lyase - metabolism
/ TyrR
2023
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Research overview of L-DOPA production using a bacterial enzyme, tyrosine phenol-lyase
Journal Article
Research overview of L-DOPA production using a bacterial enzyme, tyrosine phenol-lyase
2023
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Overview
L-DOPA is an amino acid that is used as a treatment for Parkinson’s disease. A simple enzymatic synthesis method of L-DOPA had been developed using bacterial L-tyrosine phenol-lyase (Tpl). This review describes research on screening of bacterial strains, culture conditions, properties of the enzyme, reaction mechanism of the enzyme, and the reaction conditions for the production of L-DOPA. Furthermore, molecular bleeding of constitutively Tpl-overproducing strains is described, which were developed based on mutations in a DNA binding protein, TyrR, which controls the induction of tpl gene expression.
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