Journal Article

Stromal Cell-Derived Factor 1 Polymorphism in Retinal Vein Occlusion

Lesch, Balázs, Szigeti, Andrea, Schneider, Miklós, Ecsedy, Mónika, Lénárt, Lilla, Nagy, Zoltán Zsolt, Fekete, Andrea, Récsán, Zsuzsanna

2016

Overview

Stromal cell-derived factor 1 (SDF1) has crucial role in the regulation of angiogenesis and ocular neovascularisation (NV). The purpose of this study was to evaluate the association between SDF1-3'G(801)A polymorphism and NV complications of retinal vein occlusion (RVO). 130 patients with RVO (median age: 69.0, range 35-93 years; male/female- 58/72; 55 patients had central RVO, 75 patients had branch RVO) were enrolled in this study. In the RVO group, 40 (30.8%) patients were diagnosed with NV complications of RVO and 90 (69.2%) patients without NVs. The median follow up period was 40.3 months (range: 18-57 months). The SDF1-3'G(801)A polymorphism was detected by PCR-RFLP. Allelic prevalence was related to reference values obtained in the control group consisted of 125 randomly selected, age and gender matched, unrelated volunteers (median age: 68.0, range 36-95 years; male/female- 53/72). Statistical analysis of the allele and genotype differences between groups (RVO patients vs controls; RVO patients with NV vs RVO patients without NV) was determined by chi-squared test. P value of <0.05 was considered statistically significant. Hardy-Weinberg criteria was fulfilled in all groups. The SDF1-3'G(801)A allele and genotype frequencies of RVO patients were similar to controls (SDF1-3'A allele: 22.3% vs 20.8%; SDF1-3'(801)AA: 5.4% vs 4.8%, SDF1-3'(801)GG: 60.8% vs 63.2%). The frequency of SDF1-3'(801)AA and SDF1-3'(801)GA genotypes, as well as the SDF1-3'(801)A allele frequency were higher in RVO patients with NV versus in patients without NV complication (SDF1-3'(801)AA+AG genotypes: 57.5% vs 31.1%, p = 0.008; SDF1-3'(801)A allele: 35.0% vs 16.7%, p = 0.002) or versus controls (SDF1-3'(801)AA+AG genotypes 57.5% vs 36.8%, p = 0.021; SDF1-3'(801)A allele: 35.0% vs 20.8% p = 0.01). Carrying of SDF1-3'(801)A allele increased the risk of neovascularisation complications of RVO by 2.69 (OR, 95% CI = 1.47-4.93). These findings suggest that carrying SDF1-3'(801)A allele plays a role in the development of neovascular complications in retinal vein occlusion.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Age / Aged / Aged, 80 and over / Alleles / Analysis / Angiogenesis / Biology and Life Sciences / Chemokine CXCL12 - genetics / Chemokines / Complications / Diabetes / Diabetic retinopathy / Female / Gene Frequency / Gene polymorphism / Genetic aspects / Genetic Predisposition to Disease / Genotype / Genotypes / Glaucoma / Health aspects / Humans / Laboratories / Male / Median (statistics) / Medical research / Medicine and Health Sciences / Middle Aged / Neovascularization / Nephrology / Occlusion / Patients / Pediatrics / Polymerase chain reaction / Polymorphism / Polymorphism, Genetic / Restriction fragment length polymorphism / Retina / Retinal diseases / Retinal Vein Occlusion - genetics / SDF-1 protein / Statistical analysis / Statistical tests / Stem cells / Vascular endothelial growth factor / Veins & arteries