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effects of conjugated linoleic acid supplementation on immune function in healthy volunteers
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effects of conjugated linoleic acid supplementation on immune function in healthy volunteers
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Journal Article
effects of conjugated linoleic acid supplementation on immune function in healthy volunteers
2005
Overview
Objective: To assess the effects of dietary supplementation using two isomeric blends of conjugated linoleic acid (CLA) on immune function in healthy human volunteers. Design: Double-blind, randomised, placebo-controlled intervention trial. Subjects and intervention: A total of 55 healthy volunteers (n=20 males, n=35 females) were randomised into one of three study groups who received 3 g/day of a fatty acid blend containing a 50:50 cis-9, trans-11: trans-10, cis-12 CLA isomer blend (2 g CLA), and 80:20 cis-9, trans-11: trans-10, cis-12 (80:20) CLA isomer blend (1.76 g CLA) or linoleic acid (control, 2 g linoleic acid) for 8 weeks. Results: Supplementation with the 80:20 CLA isomer blend significantly (P
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Adhesion
/ Adult
/ Biological and medical sciences
/ Female
/ Humans
/ Immunity, Cellular - drug effects
/ Immunity, Cellular - physiology
/ Intercellular adhesion molecule 1
/ Interleukin-2 - biosynthesis
/ Isomers
/ Leukocytes, Mononuclear - immunology
/ Linoleic Acid - administration & dosage
/ Linoleic Acid - pharmacology
/ Linoleic Acids, Conjugated - administration & dosage
/ Linoleic Acids, Conjugated - chemistry
/ Linoleic Acids, Conjugated - pharmacology
/ Lymphocyte Activation - drug effects
/ Male
/ Medicine
/ men
/ Peripheral blood mononuclear cells
/ serum-soluble intercellular adhesion molecule-1
/ Tumor Necrosis Factor-alpha - biosynthesis
/ women
