Journal Article

Physical and sexual abuse in childhood and adolescence and leukocyte telomere length: A pooled analysis of the study on psychosocial stress, spirituality, and health

Warner, Erica T., Kandula, Namratha R., Kanaya, Alka M., Taporoski, Tâmara P., Pereira, Alexandre, Shields, Alexandra, Palmer, Julie R., Cozier, Yvette, Tworoger, Shelley, Zhang, Ying, Gu, Yue, Cole, Shelley A., DeVivo, Immaculata, Spence, Nicholas D.

2020

Overview

We examined whether abuse in childhood and/or adolescence was associated with shorter telomere length in a pooled analysis of 3,232 participants from five diverse cohorts. We also assessed whether religion or spirituality (R/S) could buffer deleterious effects of abuse. Physical and sexual abuse in childhood (age <12) and adolescence (age 12-18) was assessed using the Revised Conflict Tactics Scale and questions from a 1995 Gallup survey. We measured relative leukocyte telomere lengths (RTL) using quantitative real time polymerase chain reaction. We used generalized estimating equations to assess associations of physical and sexual abuse with log-transformed RTL z-scores. Analyses were conducted in each cohort, overall, and stratified by extent of religiosity or spirituality and religious coping in adulthood. We pooled study-specific estimates using random-effects models and assessed between-study heterogeneity. Compared to no abuse, severe sexual abuse was associated with lower RTL z-scores, in childhood: -15.6%, 95% CI: -25.9, -4.9; p-trend = 0.04; p-heterogeneity = 0.58 and in adolescence: -16.5%, 95% CI: -28.1, -3.0; p-trend = 0.08; p-heterogeneity = 0.68. Sexual abuse experienced in both childhood and adolescence was associated with 11.3% lower RTL z-scores after adjustment for childhood and demographic covariates (95% CI: -20.5%, -2.0%; p-trend = 0.03; p-heterogeneity = 0.62). There was no evidence of effect modification by R/S. Physical abuse was not associated with telomere length. Sexual abuse in childhood or adolescence was associated with a marker of accelerated biological aging, decreased telomere length. The lack of moderation by R/S may be due to inability to capture the appropriate time period for those beliefs and practices.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Abuse / Adolescence / Adolescent / Adolescents / Aging / Cardiology / Cell division / Child / Child abuse / Child development / Childhood / Children / Consent / Epidemiology / Genetic aspects / Genomics / Health aspects / Health disparities / Heart / Heterogeneity / Hospitals / Humans / Laboratories / Leukocytes / Leukocytes - metabolism / Medical schools / Medicine / Physical Abuse / Physiological aspects / Polymerase chain reaction / Psychological aspects / Psychological stress / Questionnaires / Religion / Religiosity / Sex crimes / Sexual assault / Social interactions / Spirituality / Stress / Tactics / Teenagers / Telomerase / Telomere - genetics / Telomeres / White blood cells / Womens health