Journal Article

Folic Acid Supplementation in Pregnancy and the Risk of Pre-Eclampsia—A Cohort Study

Walker, Mark C., Yang, Qiuying, Rodger, Marc, White, Ruth Rennicks, Smith, Graeme N., Guo, Yanfang, Wen, Shi Wu, Perkins, Sherry L.

2016

Overview

This prospective cohort study designed to assess the effect of folic acid supplementation in pregnancy on the risk of preeclampsia (PE) took place in Ottawa, ON and Kingston, ON, Canada, from September 1, 2002 to August 31, 2008. Pregnant women, less than 20 weeks gestational age were recruited and delivered in the Ottawa region and the Kingston General Hospital. Demographic characteristics of the study participants and the patterns of supplementation of folic acid were described and occurrence of PE between women with folic acid supplementation during pregnancy and women without were compared. Multiple logistic regression was used in the estimation of the independent effect of supplementation of folic acid. Additional analyses assessing the effect of low RBC and serum folate and dose-response relationship were performed. Analyses were performed in all study participants, and then in high risk and low risk sub-groups, respectively. A total of 7,669 participants were included in the final analysis. Ninety five percent of the study participants were taking folic acid supplementation in early second trimester. The rate of PE was lower in the supplementation group than in the no supplementation group, and the difference was statistically significant in high risk women. Similar patterns of associations were observed in analysis by RBC and serum folate levels and in dose-response analysis. Folic acid supplementation in pregnancy may reduce PE risk in pregnant women, especially in those women with increased risk of developing PE.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Acids / Adult / Canada / Cohort analysis / Cohort Studies / Complications and side effects / Demographics / Dietary Supplements / Dosage and administration / Female / Folic acid / Folic Acid - blood / Food and nutrition / Gestational Age / Health aspects / Health risk assessment / Humans / Logistic Models / Medicine and Health Sciences / Mortality / Nutrition / Physical Sciences / Pre-eclampsia / Pre-Eclampsia - blood / Pre-Eclampsia - prevention & control / Preeclampsia / Pregnancy / Pregnant women / Prevention / Preventive medicine / Prospective Studies / Regression analysis / Research and Analysis Methods / Risk / Risk factors / Statistical analysis / Supplements / Womens health / Young Adult