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Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure

by Esham, Heather , Stevens, Stephen , Johnson, Joshua A. , Ricks, Keersten M. , Bellanca, Stephanie , Fiallos, Jimmy , Johnston, Sara C. , Klosterman, Leslie , Danner, Denise , Scruggs, Jennifer , Paz, Fabian , Shamblin, Joshua , Giles, Wendy , Raymond, Jo Lynne , Shoemaker, Charles J. , Kim, Ruth , Clements, Tamara L. , Bowling, Philip , White, Lauren , Delp, Korey L. , Ghering, Jeanean , Kugelman, Jeffrey R. , Frick, Ondraya , Akers, Kristen , Minogue, Timothy D. , Nalca, Aysegul , Jensen, Christopher , Alli, Nazira , Jay, Alexandra , Rossi, Franco , Nyakiti, David , Koehler, Jeffrey W. , Dyer, David , Berrier, Kerry , Durant, Matthew , Pitt, Margaret L. M. , Smith, Jeffrey M. , Kearney, Brian , Beitzel, Brett F. , Zeng, Xiankun , Gibson, Kathleen M. , Kuehnert, Paul A. , Coyne, Susan R. , Sifford, Willie , Hooper, Jay W. , Barth, James , Moore, Joshua , Garcia, Terrence

in Airborne infection / Animal models / Animal models in research / Animals / Army / Asymptomatic infection / Biology / Biology and life sciences / Chlorocebus aethiops / Congestive heart failure / Coronaviridae / Coronaviruses / Cough / COVID-19 / COVID-19 - pathology / COVID-19 - physiopathology / COVID-19 - transmission / Data analysis / Diagnostic systems / Disease Models, Animal / Disease transmission / Disease Transmission, Infectious / Editing / Female / Fever / Funding / Heart diseases / Immune response / Infectious diseases / Laboratories / Lung - pathology / Macaca fascicularis / Macaca mulatta / Mail / Male / Medical research / Medicine / Medicine and health sciences / Medicine, Experimental / Methodology / Molecular biology / Monkeys & apes / Pandemics / Pathology / Public health / Research and Analysis Methods / Respiration / Respiratory diseases / Respiratory rate / SARS-CoV-2 - physiology / Sepsis / Septic shock / Severe acute respiratory syndrome / Severe acute respiratory syndrome coronavirus 2 / Supervision / Veterinary medicine / Viral diseases / Virology / Virus Shedding

2021

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Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure

2021

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2021

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Journal Article

Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure

Esham, Heather,

Stevens, Stephen,

Johnson, Joshua A.,

Ricks, Keersten M.,

Bellanca, Stephanie,

Fiallos, Jimmy,

Johnston, Sara C.,

Klosterman, Leslie,

Danner, Denise,

Scruggs, Jennifer,

Paz, Fabian,

Shamblin, Joshua,

Giles, Wendy,

Raymond, Jo Lynne,

Shoemaker, Charles J.,

Kim, Ruth,

Clements, Tamara L.,

Bowling, Philip,

White, Lauren,

Delp, Korey L.,

Ghering, Jeanean,

Kugelman, Jeffrey R.,

Frick, Ondraya,

Akers, Kristen,

Minogue, Timothy D.,

Nalca, Aysegul,

Jensen, Christopher,

Alli, Nazira,

Jay, Alexandra,

Rossi, Franco,

Nyakiti, David,

Koehler, Jeffrey W.,

Dyer, David,

Berrier, Kerry,

Durant, Matthew,

Pitt, Margaret L. M.,

Smith, Jeffrey M.,

Kearney, Brian,

Beitzel, Brett F.,

Zeng, Xiankun,

Gibson, Kathleen M.,

Kuehnert, Paul A.,

Coyne, Susan R.,

Sifford, Willie,

Hooper, Jay W.,

Barth, James,

Moore, Joshua,

Garcia, Terrence

2021

Overview

Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comparative evaluation of COVID-19 in African green monkeys, rhesus macaques, and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to determine critical disease parameters associated with disease progression, and establish correlations between primate and human COVID-19. Respiratory abnormalities and viral shedding were noted for all animals, indicating successful infection. Cynomolgus macaques developed fever, and thrombocytopenia was measured for African green monkeys and rhesus macaques. Type II pneumocyte hyperplasia and alveolar fibrosis were more frequently observed in lung tissue from cynomolgus macaques and African green monkeys. The data indicate that, in addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Airborne infection

/ Animal models

/ Animal models in research

/ Animals

/ Army

/ Asymptomatic infection

/ Biology