Asset Details
Do you wish to reserve the book?
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
Do you wish to request the book?
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
2014
Overview
Hashizume
et al
. report a new therapeutic strategy for treating pediatric gliomas with mutations in the
H3F3A
gene by inhibiting histone demethylation.
Pediatric brainstem gliomas often harbor oncogenic K27M mutation of histone H3.3. Here we show that GSKJ4 pharmacologic inhibition of K27 demethylase JMJD3 increases cellular H3K27 methylation in K27M tumor cells and demonstrate potent antitumor activity both
in vitro
against K27M cells and
in vivo
against K27M xenografts. Our results demonstrate that increasing H3K27 methylation by inhibiting K27 demethylase is a valid therapeutic strategy for treating K27M-expressing brainstem glioma.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 13/109
/ 13/2
/ 13/31
/ 13/51
/ 13/89
/ 14/19
/ 14/34
/ 14/35
/ 14/63
/ 38/22
/ 38/23
/ 45/61
/ 45/77
/ 45/90
/ 59/5
/ 64/60
/ 82/16
/ 82/29
/ Animals
/ Brain Stem Neoplasms - genetics
/ Brain Stem Neoplasms - metabolism
/ Cell Proliferation - drug effects
/ Child
/ Gene Expression Regulation, Neoplastic
/ Gliomas
/ Histones
/ Humans
/ Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors
/ Jumonji Domain-Containing Histone Demethylases - metabolism
/ Mice
/ Mutation
/ Tumors
