Journal Article

Population Structure and Antimicrobial Resistance in Campylobacter jejuni and C. coli Isolated from Humans with Diarrhea and from Poultry, East Africa

French, Nigel P., Kasagama, Elizabeth, Verani, Jennifer R., Crump, John A., Maganga, Ruth, Ochieng, John B., Zadoks, Ruth N., Hugho, Ephrasia A., Swai, Emanuel S., Kazwala, Rudovick R., Wilkinson, David A., Rogers, Lynn, Mosha, Victor V., Bigogo, Godfrey M., Midwinter, Anne C., Thomas, Kate M., Amani, Nelson B., Mshana, Fadhili I., Sindiyo, Emmanuel, Melubo, Matayo L., Cleaveland, Sarah, Mmbaga, Blandina T., Widdowson, Marc-Alain, Karimuribo, Esron D., Fayaz, Ahmed, Benschop, Jackie, Munyua, Peninah

2024

Overview

Campylobacteriosis and antimicrobial resistance (AMR) are global public health concerns. Africa is estimated to have the world's highest incidence of campylobacteriosis and a relatively high prevalence of AMR in Campylobacter spp. from humans and animals. Few studies have compared Campylobacter spp. isolated from humans and poultry in Africa using whole-genome sequencing and antimicrobial susceptibility testing. We explored the population structure and AMR of 178 Campylobacter isolates from East Africa, 81 from patients with diarrhea in Kenya and 97 from 56 poultry samples in Tanzania, collected during 2006-2017. Sequence type diversity was high in both poultry and human isolates, with some sequence types in common. The estimated prevalence of multidrug resistance, defined as resistance to >3 antimicrobial classes, was higher in poultry isolates (40.9%, 95% credible interval 23.6%-59.4%) than in human isolates (2.5%, 95% credible interval 0.3%-6.8%), underlining the importance of antimicrobial stewardship in livestock systems.

• Publisher: U.S. National Center for Infectious Diseases,Centers for Disease Control and Prevention
• Subject: Africa, Eastern - epidemiology / and / Animals / Anti-Bacterial Agents - pharmacology / Antimicrobial agents / antimicrobial resistance / bacteria / Campylobacter / Campylobacter coli / Campylobacter coli - drug effects / Campylobacter coli - genetics / Campylobacter coli - isolation & purification / Campylobacter Infections - drug therapy / Campylobacter Infections - epidemiology / Campylobacter Infections - microbiology / Campylobacter Infections - veterinary / Campylobacter jejuni / Campylobacter jejuni - drug effects / Campylobacter jejuni - genetics / Campylobacter jejuni - isolation & purification / campylobacteriosis / Datasets / Diarrhea / Diarrhea - drug therapy / Diarrhea - epidemiology / Diarrhea - microbiology / Disease transmission / Diseases / Drug resistance / Drug resistance in microorganisms / Drug Resistance, Bacterial / Drug Resistance, Multiple, Bacterial / Farms / Genes / Genetic aspects / Genomics / Glycerol / Health surveillance / Humans / Identification and classification / Isolated from Humans with Diarrhea and from Poultry, East Africa / Livestock / Medical laboratories / Medical research / Methods / Microbial Sensitivity Tests / Microbiological research / Pathogens / Phylogeny / Physiological aspects / Population structure / Population Structure and Antimicrobial Resistance in / Poultry / Poultry - microbiology / Poultry Diseases - drug therapy / Poultry Diseases - epidemiology / Poultry Diseases - microbiology / Poultry industry / Public health / Research centers / Research ethics / Tetracycline / Tetracyclines / Whole Genome Sequencing