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Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study
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Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study
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Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study
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Journal Article
Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study
2013
Overview
We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR’s (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).
Publisher
Springer US,Springer,Springer Nature B.V
Subject
/ Antipyretics - adverse effects
/ Antipyretics - therapeutic use
/ Autism
/ Autistic Disorder - etiology
/ Behavioral Science and Psychology
/ Biological and medical sciences
/ Child Development Disorders, Pervasive - etiology
/ Children
/ Developmental Disabilities - etiology
/ Developmentally delayed children
/ Female
/ Fever
/ Fevers
/ Genetics
/ Humans
/ Influenza, Human - complications
/ Male
/ Mothers
/ Pregnancy Complications, Infectious - virology
/ Prenatal Exposure Delayed Effects - psychology
/ Psychology. Psychoanalysis. Psychiatry
/ Risk
/ Viral diseases of the respiratory system and ent viral diseases
