Journal Article

A positively selected FBN1 missense variant reduces height in Peruvian individuals

Calderon, Roger, Selig, Martin, Murray, Megan B., O’Connor, Timothy D., Slowikowski, Kamil, Raychaudhuri, Soumya, Farroñay, Chandel, Nazarian, Rosalynn M., Guio, Heinner, Hirschhorn, Joel N., Jimenez, Judith, Coit, Julia M., Yataco, Rosa, Asgari, Samira, Luo, Yang, Freeman, Esther E., Galea, Jerome T., Belbin, Gillian M., Harris, Daniel N., Bartell, Eric, Dietz, Harry C., Contreras, Carmen, Kenny, Eimear E., Akbari, Ali, Li, Xinyi, Lecca, Leonid

2020

Overview

On average, Peruvian individuals are among the shortest in the world 1 . Here we show that Native American ancestry is associated with reduced height in an ethnically diverse group of Peruvian individuals, and identify a population-specific, missense variant in the FBN1 gene (E1297G) that is significantly associated with lower height. Each copy of the minor allele (frequency of 4.7%) reduces height by 2.2 cm (4.4 cm in homozygous individuals). To our knowledge, this is the largest effect size known for a common height-associated variant. FBN1 encodes the extracellular matrix protein fibrillin 1, which is a major structural component of microfibrils. We observed less densely packed fibrillin-1-rich microfibrils with irregular edges in the skin of individuals who were homozygous for G1297 compared with individuals who were homozygous for E1297. Moreover, we show that the E1297G locus is under positive selection in non-African populations, and that the E1297 variant shows subtle evidence of positive selection specifically within the Peruvian population. This variant is also significantly more frequent in coastal Peruvian populations than in populations from the Andes or the Amazon, which suggests that short stature might be the result of adaptation to factors that are associated with the coastal environment in Peru. In an ethnically diverse group of Peruvian individuals, the population-specific, missense variant in FBN1 (E1297G) is associated with lower height and shows evidence of positive selection within the Peruvian population.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 13 / 13/51 / 14/1 / 14/19 / 14/28 / 45 / 45/22 / 45/43 / 631/181/457/649 / 631/208/182 / 631/208/205/2138 / Body Height - genetics / Coastal environments / Confidence intervals / Extracellular matrix / Female / Fibrillin / Fibrillin-1 - genetics / Gene Frequency / Genome-Wide Association Study / Haplotypes / Heredity / Humanities and Social Sciences / Humans / Hypotheses / Indians, South American - genetics / Male / Matrix protein / Microfibrils / Microfibrils - chemistry / Microfibrils - genetics / Minority & ethnic groups / multidisciplinary / Mutation, Missense / Observations / Peru / Population / Populations / Positive selection / Science / Science (multidisciplinary) / Selection, Genetic / Stature