Asset Details
Do you wish to reserve the book?
Gene expression variability across cells and species shapes innate immunity
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Gene expression variability across cells and species shapes innate immunity
Do you wish to request the book?
Gene expression variability across cells and species shapes innate immunity
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Gene expression variability across cells and species shapes innate immunity
2018
Overview
As the first line of defence against pathogens, cells mount an innate immune response, which varies widely from cell to cell. The response must be potent but carefully controlled to avoid self-damage. How these constraints have shaped the evolution of innate immunity remains poorly understood. Here we characterize the innate immune response’s transcriptional divergence between species and variability in expression among cells. Using bulk and single-cell transcriptomics in fibroblasts and mononuclear phagocytes from different species, challenged with immune stimuli, we map the architecture of the innate immune response. Transcriptionally diverging genes, including those that encode cytokines and chemokines, vary across cells and have distinct promoter structures. Conversely, genes that are involved in the regulation of this response, such as those that encode transcription factors and kinases, are conserved between species and display low cell-to-cell variability in expression. We suggest that this expression pattern, which is observed across species and conditions, has evolved as a mechanism for fine-tuned regulation to achieve an effective but balanced response.
Comparison of transcriptomic data from immune-stimulated cells across different species sheds light on the architecture of the innate immune response.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38/91
/ 64
/ Acids
/ Animals
/ Genes
/ Genomes
/ Genomics
/ Humanities and Social Sciences
/ Humans
/ Immunity
/ Immunity, Innate - immunology
/ Kinases
/ Mammals
/ Organ Specificity - genetics
/ Promoter Regions, Genetic - genetics
/ Proteins
/ Science
/ Species
