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The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury
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The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury
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Journal Article
The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury
2016
Overview
Reperfusion after a period of ischemia results in reperfusion injury (IRI) which involves activation of the inflammatory cascade. In cardiac IRI, IgM natural antibodies (NAb) play a prominent role through binding to altered neoepitopes expressed on damaged cells. Beta 2 Glycoprotein I (β2GPI) is a plasma protein that binds to neoepitopes on damaged cells including anionic phospholipids through its highly conserved Domain V. Domain I of β2GPI binds circulating IgM NAbs and may provide a link between the innate immune system, IgM NAb binding and cardiac IRI. This study was undertaken to investigate the role of Β2GPI and its Domain V in cardiac IRI using wild-type (WT), Rag-1 -/- and β2GPI deficient mice. Compared with control, treatment with Domain V prior to cardiac IRI prevented binding of endogenous β2GPI to post-ischemic myocardium and resulted in smaller myocardial infarction size in both WT and β2GPI deficient mice. Domain V treatment in WT mice also resulted in less neutrophil infiltration, less apoptosis and improved ejection fraction at 24 h. Rag-1 -/- antibody deficient mice reconstituted with IgM NAbs confirmed that Domain V prevented IgM NAb induced cardiac IRI. Domain V remained equally effective when delivered at the time of reperfusion which has therapeutic clinical relevance.Based upon this study Domain V may function as a universal inhibitor of IgM NAb binding in the setting of cardiac IRI, which offers promise as a new therapeutic strategy in the treatment of cardiac IRI.
Publisher
Public Library of Science (PLoS),Public Library of Science
Subject
/ Animals
/ beta 2-Glycoprotein I - genetics
/ beta 2-Glycoprotein I - immunology
/ beta 2-Glycoprotein I - pharmacology
/ Binding
/ Damage
/ Heart
/ Immunity, Innate - drug effects
/ Immunoglobulin M - immunology
/ Ischemia
/ Ligands
/ Medicine
/ Medicine and Health Sciences
/ Mice
/ Myocardial Reperfusion Injury
/ Myocardial Reperfusion Injury - genetics
/ Myocardial Reperfusion Injury - immunology
/ Myocardial Reperfusion Injury - pathology
/ Myocardial Reperfusion Injury - prevention & control
/ Q
/ R
/ Research and Analysis Methods
/ Rodents
/ Science
