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Msx1 Cooperates with Histone H1b for Inhibition of Transcription and Myogenesis
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Msx1 Cooperates with Histone H1b for Inhibition of Transcription and Myogenesis
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Journal Article
Msx1 Cooperates with Histone H1b for Inhibition of Transcription and Myogenesis
2004
Overview
During embryogenesis, differentiation of skeletal muscle is regulated by transcription factors that include members of the Msx homeoprotein family. By investigating Msx1 function in repression of myogenic gene expression, we identified a physical interaction between Msx1 and H1b, a specific isoform of mouse histone H1. We found that Msx1 and H1b bind to a key regulatory element of MyoD, a central regulator of skeletal muscle differentiation, where they induce repressed chromatin. Moreover, Msx1 and H1b cooperate to inhibit muscle differentiation in cell culture and in Xenopus animal caps. Our findings define a previously unknown function for \"linker\" histones in gene-specific transcriptional regulation.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Biological and medical sciences
/ Embryo, Nonmammalian - cytology
/ Embryo, Nonmammalian - metabolism
/ Embryology: invertebrates and vertebrates. Teratology
/ Fundamental and applied biological sciences. Psychology
/ Gene Expression Regulation, Developmental
/ Genetics
/ Histones
/ Homeodomain Proteins - chemistry
/ Homeodomain Proteins - genetics
/ Homeodomain Proteins - metabolism
/ Mice
/ Muscle, Skeletal - metabolism
/ Mutation
/ Organogenesis. Fetal development
/ Organogenesis. Physiological fonctions
/ Proteins
/ Recombinant Proteins - metabolism
/ Regulatory Sequences, Nucleic Acid
/ Transcription Factors - chemistry
/ Transcription Factors - genetics
