Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

by Montoro, Daniel T. , Reeves, Jason , Slyper, Michal , Sud, Malika , Fleming, Stephen J. , Rueckert, Erroll H. , Yang, Yiming , Pita-Juárez, Yered H. , Jiang, Z. Gordon , Atri, Deepak S. , Hung, Deborah , Essene, Adam , Farhi, Samouil L. , Brook, Olga R. , Shalek, Alex K. , McLoughlin, Daniel E. , Dey, Kushal K. , Dorceus, Phylicia , Niezen, Sebastian , Todres, Ellen , Rogers, Robert , Heimberg, Graham , Price, Alkes L. , Gould, Joshua , Divakar, Prajan , Novak, Richard , Hibshoosh, Hanina , Tickle, Timothy L. , Tsai, Linus T.-Y. , Ellinor, Patrick T. , Hide, Winston , Tata, Purushothama Rao , Ingber, Donald E. , Plaisted, Jacob , Wang, Yiping , Segerstolpe, Åsa , Normand, Rachelly , Miller, Eric M. , Zhang, Shuting , Hether, Tyler , Raju, Siddharth S. , Stone, James R. , Ganna, Andrea , Pfiffner-Borges, Jenna , Rudy, Melissa , Vlachos, Ioannis S. , Pinto, Christopher J. , Engreitz, Jesse M. , McCabe, Cristin , Gomez, James , Villani, Alexandra-Chloé , Ashenberg, Orr , Bloom-Ackermann, Zohar , Jané-Valbuena, Judit , Solomon, Isaac H. , Li, Bo , Pant, Deepti , Barkas, Nikolaos , Popov, Yury V. , Gazal, Steven , Siddle, Katherine J. , Delorey, Toni M. , Fitzgerald, Donna

in 38 / 45/91 / 631/208 / 631/250/255/2514 / 631/326/596/4130 / Adult / Aged / Aged, 80 and over / Alveoli / Annotations / Atlases as Topic / Autopsies / Autopsy / Biobanks / Biological effects / Biological Specimen Banks / Cells (biology) / Computer applications / Coronaviruses / COVID-19 / COVID-19 - genetics / COVID-19 - immunology / COVID-19 - pathology / COVID-19 - virology / Endothelial Cells / Epithelial Cells - pathology / Epithelial Cells - virology / Female / Fibroblasts / Genome-wide association studies / Genome-Wide Association Study / Genomes / Heart / Heart - virology / Humanities and Social Sciences / Humans / Infections / Inflammation / Inflammation - pathology / Inflammation - virology / Kidney - pathology / Kidney - virology / Liver / Liver - pathology / Liver - virology / Lung - pathology / Lung - virology / Lungs / Male / Middle Aged / multidisciplinary / Myocardium - pathology / Organ Specificity / Pathophysiology / Phagocytes / Progenitor cells / Pulmonary Alveoli - pathology / Pulmonary Alveoli - virology / Regeneration / Respiratory distress syndrome / RNA, Viral - analysis / SARS-CoV-2 - immunology / SARS-CoV-2 - pathogenicity / Science / Science (multidisciplinary) / Severe acute respiratory syndrome coronavirus 2 / Single-Cell Analysis / Spatial analysis / Stem cells / Tissue engineering / Tissues / Transcription / Viral diseases / Viral Load

2021

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

2021

Confirm

Do you wish to request the book?

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

2021

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

Montoro, Daniel T.,

Reeves, Jason,

Slyper, Michal,

Sud, Malika,

Fleming, Stephen J.,

Rueckert, Erroll H.,

Yang, Yiming,

Pita-Juárez, Yered H.,

Jiang, Z. Gordon,

Atri, Deepak S.,

Hung, Deborah,

Essene, Adam,

Farhi, Samouil L.,

Brook, Olga R.,

Shalek, Alex K.,

McLoughlin, Daniel E.,

Dey, Kushal K.,

Dorceus, Phylicia,

Niezen, Sebastian,

Todres, Ellen,

Rogers, Robert,

Heimberg, Graham,

Price, Alkes L.,

Gould, Joshua,

Divakar, Prajan,

Novak, Richard,

Hibshoosh, Hanina,

Tickle, Timothy L.,

Tsai, Linus T.-Y.,

Ellinor, Patrick T.,

Hide, Winston,

Tata, Purushothama Rao,

Ingber, Donald E.,

Plaisted, Jacob,

Wang, Yiping,

Segerstolpe, Åsa,

Normand, Rachelly,

Miller, Eric M.,

Zhang, Shuting,

Hether, Tyler,

Raju, Siddharth S.,

Stone, James R.,

Ganna, Andrea,

Pfiffner-Borges, Jenna,

Rudy, Melissa,

Vlachos, Ioannis S.,

Pinto, Christopher J.,

Engreitz, Jesse M.,

McCabe, Cristin,

Gomez, James,

Villani, Alexandra-Chloé,

Ashenberg, Orr,

Bloom-Ackermann, Zohar,

Jané-Valbuena, Judit,

Solomon, Isaac H.,

Li, Bo,

Pant, Deepti,

Barkas, Nikolaos,

Popov, Yury V.,

Gazal, Steven,

Siddle, Katherine J.,

Delorey, Toni M.,

Fitzgerald, Donna

2021

Overview

COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple organ failure 1 – 4 , but little is known about its pathophysiology. Here we generated single-cell atlases of 24 lung, 16 kidney, 16 liver and 19 heart autopsy tissue samples and spatial atlases of 14 lung samples from donors who died of COVID-19. Integrated computational analysis uncovered substantial remodelling in the lung epithelial, immune and stromal compartments, with evidence of multiple paths of failed tissue regeneration, including defective alveolar type 2 differentiation and expansion of fibroblasts and putative TP63 + intrapulmonary basal-like progenitor cells. Viral RNAs were enriched in mononuclear phagocytic and endothelial lung cells, which induced specific host programs. Spatial analysis in lung distinguished inflammatory host responses in lung regions with and without viral RNA. Analysis of the other tissue atlases showed transcriptional alterations in multiple cell types in heart tissue from donors with COVID-19, and mapped cell types and genes implicated with disease severity based on COVID-19 genome-wide association studies. Our foundational dataset elucidates the biological effect of severe SARS-CoV-2 infection across the body, a key step towards new treatments. Single-cell analysis of lung, heart, kidney and liver autopsy samples shows the molecular and cellular changes and immune response resulting from severe COVID-19 infection.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ 45/91

/ 631/208

/ 631/250/255/2514

/ 631/326/596/4130

/ Adult

/ Aged

/ Aged, 80 and over