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8145 Are your vaccinations up to date? Vaccination uptake in down’s
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8145 Are your vaccinations up to date? Vaccination uptake in down’s
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Journal Article
8145 Are your vaccinations up to date? Vaccination uptake in down’s
2025
Overview
Why did you do this work?People with Trisomy 21 have an increased susceptibility to infection, particularly respiratory infection, characterised by increased frequency, severity and prolonged course of disease. Vaccination is one of the most effective public health interventions and particularly important in clinically vulnerable conditions including Trisomy 21. The aim of this project was to determine the vaccination coverage in children <18 years with Trisomy 21 attending community paediatric clinics across our healthcare trust.What did you do?Children aged <18 years (in October 2024) with Trisomy 21 attending community paediatric clinics across our healthcare trust were identified retrospectively using phlebotomy clinic lists over the previous 12 months and the trust’s electronic database (PARIS). Vaccination records for this cohort were obtained from the regional Child Health department. Data was gathered including: age, preschool vaccination history, childhood flu vaccination history for the 2023/24 flu season (in children >2 years). The vaccination coverage in children with Trisomy 21 was compared with current vaccination coverage across Northern Ireland (NI) in the Public Health Agency’s (PHA) Annual Surveillance Report1 and Annual Immunisation Reports.2 What did you find?97 patients were identified with a median age of 7 years (range 1–17 years). Of these 68% were school age (currently >5 years) and 32% were preschool age (currently <5 years) in the 2023/24 flu season. In the school age group, 100% of patients had partially completed their preschool vaccinations with 88% having fully completed. The table 1 below shows a breakdown of preschool vaccination coverage:Abstract 8145 Table 1Preschool vaccination coverage in children (>5 years) with trisomy 21 compared with NI coverage Vaccination Trisomy 21 All Children MMR1 98.4% 93.3% MMR2 92.0% 85.6% DTaP/IPV/Hib/Hep B 98.0% 94.8% DTAP/IPV Booster 93.9% 86.2% The uptake of the childhood flu vaccination by age group in the 2023/24 season is shown in the table 2 below:Abstract 8145 Table 2Childhood flu vaccination uptake in children with trisomy 21 compared with NI uptake Age Group Trisomy 21 All Children Preschool (2–4 years) 6.0% 32.9% Age 4–11 years 33.0% 68.6% Year 8–12 20.0% 56.5% What does it mean?The preschool vaccination coverage in children with Trisomy 21 is above the regional figures. The childhood flu vaccination uptake in children with Trisomy 21 is however markedly lower than the regional uptake, especially in the preschool age group. Now that this discrepancy has been highlighted, the community paediatric team can focus on developing interventions to improve the flu vaccination uptake in this patient cohort for the 2024/25 flu season.ReferencesPublic Health Agency. Annual Surveillance Report. Accessed via URL: https://www.publichealth.hscni.net/directorates/public-health/health-protection/surveillance-data/respiratory-infections/seasonal-1#vaccinationPublic Health Agency. Annual Immunisation Report: Northern Ireland vaccination coverage at 5 years of age. Accessed via URL: https://www.publichealth.hscni.net/directorate-public-health/health-protection/vaccination-coverage
