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Spatially divergent metabolic impact of experimental toxoplasmosis: immunological and microbial correlates
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Spatially divergent metabolic impact of experimental toxoplasmosis: immunological and microbial correlates
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Journal Article
Spatially divergent metabolic impact of experimental toxoplasmosis: immunological and microbial correlates
2025
Overview
Inflammation is a major driver of tissue perturbation. However, the signals driving these changes on a tissue-intrinsic and molecular level are poorly understood. This study evaluated tissue-specific metabolic perturbations across 11 sampling sites following systemic murine infection with the parasite Toxoplasma gondii . Results revealed relationships between differential metabolite enrichment and variables, including inflammatory signals, pathogen burden, and commensal microbial communities. These data will inform hypotheses about the signals driving specific metabolic adaptation in acute and chronic protozoan infection, with broader implications for infection and inflammation in general.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Animals
/ Clinical Microbiology and Infectious Diseases
/ Cysts
/ Female
/ HIV
/ Human immunodeficiency virus
/ Liver
/ Mice
/ Microbial Pathogenesis and Immunology
/ Protozoa
/ Sampling
/ Software
/ Toxoplasmosis - parasitology
/ Toxoplasmosis, Animal - immunology
/ Toxoplasmosis, Animal - metabolism
/ Toxoplasmosis, Animal - parasitology
/ Zoonoses
