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Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent
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Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent
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Journal Article
Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent
2024
Overview
Vector-borne diseases are a leading cause of death and illness worldwide, and more than 80% of the global population live in areas at risk from at least one major vector-borne disease. In this study, we demonstrate a dual role of a specific Ixodes tick protein disulfide isomerase (PDI) in inhibiting the ability of the Lyme disease agent to colonize ticks and also in enhancing the initial stage of spirochete infection of mice. This study represents a novel conceptual advancement that a PDI from a blood-feeding vector plays important roles in the life cycle of an extracellular pathogen.
Publisher
American Society for Microbiology
Subject
/ Arthropod Proteins - genetics
/ Arthropod Proteins - metabolism
/ Blood
/ Borrelia burgdorferi - enzymology
/ Borrelia burgdorferi - genetics
/ Borrelia burgdorferi - pathogenicity
/ Feeding
/ Female
/ Mice
/ Midgut
/ Peptides
/ Protein disulfide reductase (glutathione)
/ Protein Disulfide-Isomerases - genetics
/ Protein Disulfide-Isomerases - metabolism
/ Proteins
/ tick
/ Trypsin
