Journal Article

Microbiome gut community structure and functionality are associated with symptom severity in non-responsive celiac disease patients undergoing a gluten-free diet

Marcos-Zambrano, Laura Judith, Valdés, Alberto, Loria-Kohen, Viviana, Cifuentes, Alejandro, Carrillo de Santa Pau, Enrique, Marcos-Pasero, Helena, Ramirez de Molina, Ana, Diaz-Ruiz, Alberto, Pancaldi, Vera, Aguilar-Aguilar, Elena, Lacruz-Pleguezuelos, Blanca

2025

Overview

Celiac disease (CD) is a chronic immune-mediated systemic disorder caused by consuming gluten in genetically susceptible individuals. There is currently no cure for CD, and the most effective treatment is maintaining a strict, lifelong gluten-free diet (GFD). This nutritional therapy aims to prevent the immune reaction triggered by gluten and promote the healing of the intestinal lining, resolving the clinical, serological, and histological abnormalities within 6–12 months. However, up to 30% of patients may continue to experience symptoms or exhibit laboratory abnormalities or intestinal inflammation suggestive of active CD, despite following a GFD. This challenge, which encompasses various diagnoses, is known as nonresponsive celiac disease (NRCD). In this study, we explored the role of intestinal microbiota in causing NRCD, finding an association between the persistence of symptoms and changes in mucosal integrity biomarkers, with different gut microbiome structures among NRCD patients, indicating a significant role of the microbiome in NRCD.

• Publisher: American Society for Microbiology,ASM (American Society for Microbiology) [2016-....]
• Subject: Adult / Amino acids / Anthropometry / Apolipoproteins / Bioinformatics / Celiac disease / Celiac Disease - diet therapy / Celiac Disease - metabolism / Celiac Disease - microbiology / Cholesterol / co-occurrence networks / Community structure / Compliance / Computer Science / Consent / Constipation / Cross-Sectional Studies / Diarrhea / Diet / Diet, Gluten-Free / Digestive system / Feces - microbiology / Female / Food / Gastrointestinal Microbiome - physiology / Gastrointestinal tract / Gluten / gluten-free diet / Gut microbiota / Helper cells / Human Microbiome / Humans / Inflammation / Inflammatory bowel disease / Intestinal microflora / Irritable bowel syndrome / Lactic acid / Life Sciences / Likert scale / Lymphocytes T / Male / Mannitol / Metabolites / Metabolome / Metabolomics / Metagenomics / microbiome / Microbiomes / Microbiota / Middle Aged / Mucosa / Nutrition research / Nutrition therapy / Patients / Pilot Projects / Quality of life / Questionnaires / Research Article / Severity of Illness Index / Small intestine / symptom association / Therapeutic targets