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Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
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Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
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Journal Article
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
1995
Overview
The recent positional cloning of the mouse ob gene and its human homolog has provide the basis to investigate the potential role of the ob gene product in body weight regulation. A biologically active form of recombinant mouse OB protein was overexpressed a purified to near homogeneity from a bacterial expression system. Peripheral and cent administration of microgram doses of OB protein reduced food intake and body weight of ob/ob and diet-induced obese mice but not in db/db obese mice. The behavioral effect after brain administration suggest that OB protein can act directly on neuronal net work that control feeding and energy balance
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Biological and medical sciences
/ brain
/ CEREBRO
/ Circles
/ Classical genetics, quantitative genetics, hybrids
/ Cloning
/ Diabetes
/ Diabetes Mellitus - genetics
/ Diabetes Mellitus - physiopathology
/ Diet
/ Dose-Response Relationship, Drug
/ Eating
/ Female
/ Fundamental and applied biological sciences. Psychology
/ GENE
/ GENES
/ Genetics
/ Genetics of eukaryotes. Biological and molecular evolution
/ Injections, Intraventricular
/ Leptin
/ Male
/ Mice
/ Neurons
/ Obesity
/ PESO
/ POIDS
/ PROTEINE
/ Proteins
/ Proteins - administration & dosage
/ RATON
/ Recombinant Proteins - administration & dosage
/ Recombinant Proteins - pharmacology
/ Rodents
/ SOURIS
/ SURPOIDS
/ Vehicles
