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Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC
Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC
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Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC
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Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC
Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC
Journal Article

Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC

2024
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Overview
Amivantamab, an antibody against MET and EGFR, plus lazertinib, an EGFR tyrosine kinase inhibitor, induced a response in 86% of previously untreated patients and led to a median progression-free survival of nearly 2 years.
Publisher
Massachusetts Medical Society
Subject

Acrylamides - therapeutic use

/ Adult

/ Aged

/ Aged, 80 and over

/ Aniline Compounds - therapeutic use

/ Antibodies, Bispecific

/ Antineoplastic Agents, Immunological - administration & dosage

/ Antineoplastic Agents, Immunological - adverse effects

/ Antineoplastic Combined Chemotherapy Protocols - administration & dosage

/ Antineoplastic Combined Chemotherapy Protocols - adverse effects

/ Antitumor activity

/ Carcinoma, Non-Small-Cell Lung - drug therapy

/ Carcinoma, Non-Small-Cell Lung - genetics

/ Carcinoma, Non-Small-Cell Lung - mortality

/ Carcinoma, Non-Small-Cell Lung - pathology

/ Chemotherapy

/ Confidence intervals

/ Critical Care

/ Critical Care General

/ Epidermal growth factor receptors

/ ErbB Receptors - antagonists & inhibitors

/ ErbB Receptors - genetics

/ Female

/ Hematology

/ Humans

/ Hypotheses

/ Hypothesis testing

/ Kaplan-Meier Estimate

/ Kinases

/ Lung Cancer

/ Lung Neoplasms - drug therapy

/ Lung Neoplasms - genetics

/ Lung Neoplasms - mortality

/ Lung Neoplasms - pathology

/ Magnetic resonance imaging

/ Male

/ Metastases

/ Metastasis

/ Middle Aged

/ Monoclonal antibodies

/ Morpholines - administration & dosage

/ Morpholines - adverse effects

/ Mutation

/ Non-small cell lung carcinoma

/ Oncology

/ Progression-Free Survival

/ Protein Kinase Inhibitors - administration & dosage

/ Protein Kinase Inhibitors - adverse effects

/ Pulmonary

/ Pyrazoles - administration & dosage

/ Pyrazoles - adverse effects

/ Pyrimidines - administration & dosage

/ Pyrimidines - adverse effects

/ Quinolines - therapeutic use

/ Small cell lung carcinoma

/ Statistical analysis

/ Survival analysis

/ Targeted cancer therapy

/ Treatment Outcome

/ Treatments in Oncology

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