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NHE1 gene associated with avian leukosis virus subgroup J infection in chicken
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NHE1 gene associated with avian leukosis virus subgroup J infection in chicken
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Journal Article
NHE1 gene associated with avian leukosis virus subgroup J infection in chicken
2014
Overview
As a kind of binding protein, the type 1 Na
+
/H
+
exchanger (NHE1) is a receptor for the highly pathogenic Avian leukosis viruses-J subgroup (ALV-J) in chicken. In order to investigate the potential effect of chicken
NHE1
gene on leukosis, we compared its expression between ALV-J-affected and -unaffected chicken, screened variations across the whole gene, and then performed association analysis with ALV-J affected/unaffected trait in three un-related chicken populations. We found that the
NHE1
gene expressed in four immune tissues including spleen, bursa fabricius, liver, and thymus, and its expression was significantly up-regulated in liver and thymus of ALV-J-affected chickens (with leukosis phenotype) compared to -unaffected ones (ALV-J-negative controls). Thirty-six single nucleotide polymorphisms (SNP) were identified in a 6,105 bp region of the chicken
NHE1
gene, giving rise to every 170 bp per SNP. Two SNP of g.4405A>G and g.5886C>G were genotyped with PCR-RFLP method. Results showed that g.4405A>G was significantly associated (
P
< 0.05) with ALV-J infection in all of the three chicken populations, including White Recessive Rock (WRR), Dwarf Yellow (DY) and Shiki Yellow (SY), while g.5886C>G was significantly associated (
P
< 0.05) with ALV-J infection in SY. These results indicated that the
NHE1
gene was related to ALV-J infection in chicken.
Publisher
Springer Netherlands,Springer Nature B.V
Subject
/ Animals
/ Avian Leukosis Virus - classification
/ Avian Leukosis Virus - genetics
/ Avian Leukosis Virus - immunology
/ Biomedical and Life Sciences
/ Birds
/ Chickens
/ Female
/ Genes
/ Genetic Predisposition to Disease
/ Genotype
/ liver
/ Polymorphism, Single Nucleotide
/ Poultry
/ restriction fragment length polymorphism
/ single nucleotide polymorphism
/ Sodium-Hydrogen Exchangers - genetics
/ spleen
/ Viruses
