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Unstable laboratory Wolbachia strain w-Anga is negatively correlated with Plasmodium falciparum in wild malaria vectors
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Unstable laboratory Wolbachia strain w-Anga is negatively correlated with Plasmodium falciparum in wild malaria vectors
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Journal Article
Unstable laboratory Wolbachia strain w-Anga is negatively correlated with Plasmodium falciparum in wild malaria vectors
2025
Overview
Spread of insecticides resistance threatens the control of malaria. In this context, biological control using an endosymbiotic bacterium
Wolbachia
is being explored as a complementary method for its control. However, for optimal use of this bacterium in biocontrol strategies, it is imperative to characterize it. So,
Anopheles gambiae
complex mosquitoes were collected, morphologically identified, then blood fed and gravid female mosquitoes oviposited individually. After oviposition, the species of parent was molecularly determined, along with their
w-Anga
infection status. Additionally, we performed
16SrRNA
gene sequencing of
w-Anga
-positive mosquitoes to determine their phylogeny. Finally, we amplified gene encoding the
circumsporozoite protein
to determinate their
Plasmodium falciparum
infection status and assessed the stability of
w-Anga
transmission of positive females and their offspring. From the results obtained, our
w-Anga
strains cluster with other
Wolbachia
Supergroup B strains. However, the prevalence of
Plasmodium falciparum
infection was lower in
Wolbachia
-infected females (4.59%) than in those uninfected (22.02%). Furthermore, the transmission frequency of this bacterium in infected
Anopheles coluzzii
females of the F0 generation to F1 offspring was 10.64% and 16.67% from infected females of the F1 generation to F2 offspring. This study results will serve as preliminary data for the possible use of
Wolbachia
in malaria control.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
