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Doxorubicin–Trabectedin with Trabectedin Maintenance in Leiomyosarcoma

by Isambert, Nicolas , Firmin, Nelly , Pautier, Patricia , Italiano, Antoine , Duffaud, Florence , Piperno-Neumann, Sophie , Guillemet, Cécile , Rios, Maria , Penel, Nicolas , Le Cesne, Axel , Balleyguier, Corinne , Collard, Olivier , Archambaud, Baptiste , Chevreau, Christine , Ray-Coquard, Isabelle , Boudou-Rouquette, Pascaline , Bertucci, François , Lebrun-Ly, Valérie , Kalbacher, Elsa , Bompas, Emmanuelle

in Aged / Antineoplastic Combined Chemotherapy Protocols - administration & dosage / Antineoplastic Combined Chemotherapy Protocols - adverse effects / Cancer / Chemotherapy / Combination therapy / Disease control / Doxorubicin / Doxorubicin - administration & dosage / Doxorubicin - adverse effects / Female / Gynecologic Oncology / Gynecology / Hematology / Humanities and Social Sciences / Humans / Kaplan-Meier Estimate / Leiomyosarcoma - drug therapy / Leiomyosarcoma - mortality / Leiomyosarcoma - pathology / Life Sciences / Maintenance Chemotherapy / Medical prognosis / Metastases / Metastasis / Methodology / Methods and statistics / Middle Aged / Neoplasm Staging / Neutropenia / Obstetrics / Oncology / Other Statistics / Patients / Progression-Free Survival / Sarcoma / Soft Tissue Neoplasms - drug therapy / Soft Tissue Neoplasms - mortality / Soft Tissue Neoplasms - pathology / Statistical analysis / Statistics / Survival / Survival Analysis / Trabectedin - administration & dosage / Trabectedin - adverse effects / Treatments in Oncology / Uterine Neoplasms - drug therapy / Uterine Neoplasms - mortality / Uterine Neoplasms - pathology / Uterus

2024

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Doxorubicin–Trabectedin with Trabectedin Maintenance in Leiomyosarcoma

2024

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Doxorubicin–Trabectedin with Trabectedin Maintenance in Leiomyosarcoma

2024

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Journal Article

Doxorubicin–Trabectedin with Trabectedin Maintenance in Leiomyosarcoma

Isambert, Nicolas,

Firmin, Nelly,

Pautier, Patricia,

Italiano, Antoine,

Duffaud, Florence,

Piperno-Neumann, Sophie,

Guillemet, Cécile,

Rios, Maria,

Penel, Nicolas,

Le Cesne, Axel,

Balleyguier, Corinne,

Collard, Olivier,

Archambaud, Baptiste,

Chevreau, Christine,

Ray-Coquard, Isabelle,

Boudou-Rouquette, Pascaline,

Bertucci, François,

Lebrun-Ly, Valérie,

Kalbacher, Elsa,

Bompas, Emmanuelle

2024

Overview

Among patients with leiomyosarcoma, a combination of doxorubicin and trabectedin with prolonged trabectedin maintenance therapy led to longer overall survival than doxorubicin alone (median, 33 vs. 24 months).

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Publisher

Massachusetts Medical Society

Subject

Aged

/ Antineoplastic Combined Chemotherapy Protocols - administration & dosage

/ Antineoplastic Combined Chemotherapy Protocols - adverse effects

/ Cancer

/ Chemotherapy

/ Combination therapy

/ Disease control