Journal Article

Sellar and parasellar lesions in the transition age: a retrospective Italian multi-centre study

Feola, T., Pirchio, R.sa, Puliani, G., Gianfrilli, D., Appetecchia, M., Pofi, R., Isidori, A. M., Di Iorgi, N., Jaffrain-Rea, M. L., Verdecchia, F., Sesti, F., Grossman, A. B., Crocco, M., Sada, V., Pivonello, R., Sbardella, E.

2023

Overview

Background Sellar/parasellar lesions have been studied in the adult and paediatric age range, but during the transition age their epidemiology, clinical manifestations, management and treatment outcomes have been poorly investigated. Materials and methods An Italian multicentre cohort study, in which hospital records of patients with diagnosis of sellar/parasellar lesions during the transition age and young adulthood (15–25 years), were reviewed in terms of prevalence, clinical and hormonal features at diagnosis, and outcomes where available. Both pituitary neuroendocrine tumours (pituitary tumours, Group A) and non-endocrine lesions (Group B) were included. Results Among Group A ( n  = 170, 46.5% macroadenomas), the most frequent were prolactin and GH-secreting tumours, with a female predominance. Among Group B ( n  = 28), germinomas and Rathke cells cysts were the most common. In Group A, the most frequent hormonal deficiency was gonadal dysfunction. Galactorrhoea and amenorrhoea were relatively common in female patients with prolactinomas. Pre-surgical diabetes insipidus was only seen in Group B, in which also hormone deficiencies were more frequent and numerous. Larger lesions were more likely to be seen in Group B. Patients in Group B were more frequently male, younger, and leaner than those of Group A, whereas at last follow-up they showed more obesity and dyslipidaemia. In our cohort, the percentage of patients with at least one pituitary deficiency increased slightly after surgery. Conclusions The management of sellar/parasellar lesions is challenging in the transition age, requiring an integrated and multidisciplinary approach. Hormone and metabolic disorders can occur many years after treatment, therefore long-term follow-up is mandatory.

• Publisher: Springer International Publishing,Springer Nature B.V
• Subject: Adolescence / Adult / Age / Age groups / Brain cancer / Brain tumors / Child / Child development / Childhood / Children & youth / Cohort Studies / Diabetes insipidus / Diagnosis / Dyslipidemia / Endocrinology / Epidemiology / Female / Females / Growth hormones / Headaches / Hormones / Hospitals / Humans / Internal Medicine / Lesions / Male / Medicine / Medicine & Public Health / Metabolic Diseases / Metabolic disorders / Neuroendocrine tumors / Original / Original Article / Overweight / Patients / Pediatrics / Pituitary / Pituitary Gland - pathology / Pituitary Neoplasms - epidemiology / Pituitary Neoplasms - pathology / Pituitary Neoplasms - therapy / Prolactin / Puberty / Retrospective Studies / Tumors / Young Adult