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A Mechanophenotyping chip for high-throughput detection of metastatic bacteria-infected circulating tumor cells
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A Mechanophenotyping chip for high-throughput detection of metastatic bacteria-infected circulating tumor cells
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Journal Article
A Mechanophenotyping chip for high-throughput detection of metastatic bacteria-infected circulating tumor cells
2026
Overview
Emerging evidence underscores biophysical characteristics of cancer cells as key modulators of cancer progression and metastasis. Herein, we reported a cell-mechanophenotyping screening microfluidic chip (termed LesM) for the high-efficient capture of circulating tumor cells (CTCs) and evaluation of single-cell deformation to reveal the hematogenous metastatic potential of bacteria-infected breast cancer. LesM employs L-shaped traps to capture single cells, leveraging bacteria-infected CTCs with cytoskeletal reorganization traverse narrowed channels while rigid native cells are retained. The platform demonstrates an average single-cell capture efficiency of 95.42% and specificity of 85.34% in discriminating infected versus non-infected breast cancer cells, validated through parallel in vivo metastatic assays. LesM enables high-throughput sensing up to 10,240 cells of mechanical signatures and microbial cargo, correlating with metastatic risk and antibiotic response. By bridging biomechanics and intratumoral microbiota detection, LesM offers a transformative liquid biopsy tool for predicting distant metastasis and guiding antimicrobial therapies in bacteria-infected breast cancers.
Emerging evidence underscores biophysical characteristics of cancer cells as key modulators of cancer metastasis. Here, the authors reported a single-cell mechanophenotyping chip that screens deformable CTCs to reveal the hematogenous metastatic potential of bacteria-infected breast cancer.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 49/62
/ Animals
/ Bacteria
/ Bacteria - isolation & purification
/ Biopsy
/ Breast Neoplasms - microbiology
/ Breast Neoplasms - pathology
/ Cells
/ Design
/ Female
/ High-Throughput Screening Assays - instrumentation
/ High-Throughput Screening Assays - methods
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Microfluidic Analytical Techniques - instrumentation
/ Microfluidic Analytical Techniques - methods
/ Neoplastic Cells, Circulating - pathology
/ Science
/ Single-Cell Analysis - instrumentation
/ Single-Cell Analysis - methods
/ Tumors
