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A novel computational model of human iPSC-derived ventricular myocytes with improved L-type calcium current for application to Timothy syndrome
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A novel computational model of human iPSC-derived ventricular myocytes with improved L-type calcium current for application to Timothy syndrome
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Journal Article
A novel computational model of human iPSC-derived ventricular myocytes with improved L-type calcium current for application to Timothy syndrome
2026
Overview
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a powerful platform for modeling inherited arrhythmias, yet current
in silico
representations face limitations in Ca
2+
handling. Here, we present a novel ventricular hiPSC-CM ionic model incorporating a Markovian formulation of the L-type Ca
2+
current (I
), tailored to better recapitulate Ca
dynamics and voltage-dependent inactivation. The model was calibrated against experimental data from hiPSC-CMs derived from a healthy individual and validated through a series of simulations relevant to both physiological and pathological conditions. These included pharmacological inhibition of I
with nifedipine, Ca
overload and DAD-mediated triggered activity, and the interplay between intracellular Ca
cycling and membrane mechanisms in driving automaticity. Sensitivity analysis was used to generate a population of models capturing intercellular variability. In addition, the model was able to reproduce the effects of genetic mutations in the L-type Ca
channel, including those associated with Timothy Syndrome, providing an additional layer of validation. Overall, this computational framework offers a flexible and physiologically grounded tool for investigating the mechanisms of arrhythmogenesis in hiPSC-CMs and for supporting personalized medicine applications.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/532
/ 631/80
/ 692/4019
/ Calcium Channels, L-Type - genetics
/ Calcium Channels, L-Type - metabolism
/ Glucose
/ Heart
/ Heart Ventricles - metabolism
/ Human induced pluripotent stem cells-derived cardiomyocytes
/ Humanities and Social Sciences
/ Humans
/ Induced Pluripotent Stem Cells - cytology
/ Induced Pluripotent Stem Cells - metabolism
/ Insulin
/ Long QT Syndrome - metabolism
/ Long QT Syndrome - pathology
/ Long QT Syndrome - physiopathology
/ Mutation
/ Myocytes
/ Myocytes, Cardiac - cytology
/ Myocytes, Cardiac - metabolism
/ Science
