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Identification of a novel natural compound that acts on the membrane progestin receptor α (paqr7) from the marine algae Padina
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Identification of a novel natural compound that acts on the membrane progestin receptor α (paqr7) from the marine algae Padina
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Journal Article
Identification of a novel natural compound that acts on the membrane progestin receptor α (paqr7) from the marine algae Padina
2026
Overview
Previously, we identified water-soluble compounds with membrane progestin receptor α (mPRα)-binding activity from the marine algae
Padina arborescens
. The compounds inhibited fish oocyte maturation. These compounds are potentially novel antagonists of mPR and are of interest as novel inhibitors of the nongenomic pathway of steroids. In this study, a compound with mPRα binding activity was purified from the methanol extract of
Padina
tarries. The structure of one of the major compounds in the fraction was identified as 1-carboxybutyl-2-hydroxypentanoate (1-CB 2-HPNA) using nuclear magnetic resonance spectroscopy and ESI–MS analysis. 1-CB 2-HPNA showed substantial competitive binding affinity for human mPRα (hmPRα) in the graphene quantum dot (GQD)-hmPRα binding assay. The physiological activity of 1-CB 2-HPNA was then evaluated using an in vitro and in vivo zebrafish oocyte maturation and ovulation assay. 1-CB 2-HPNA inhibited the maturation and ovulation of fish oocytes. In addition, 1-CB 2-HPNA inhibited ovulation in mice. These results indicate that 1-CB 2-HPNA, identified from
Padina arborescens
, is a novel natural mPRα antagonist.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Algae
/ Animals
/ Biological Products - chemistry
/ Biological Products - isolation & purification
/ Biological Products - pharmacology
/ Ethanol
/ Female
/ Humanities and Social Sciences
/ Humans
/ Magnetic resonance spectroscopy
/ Mice
/ NMR
/ Oocytes
/ Padina
/ Receptors, Progesterone - antagonists & inhibitors
/ Receptors, Progesterone - metabolism
/ Science
