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Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility
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Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility
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Journal Article
Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility
2010
Overview
Soluble carbon nanotubes show promise as materials for
in vivo
delivery and imaging applications. Several reports have described the
in vivo
toxicity of carbon nanotubes, but their effects on male reproduction have not been examined. Here, we show that repeated intravenous injections of water-soluble multiwalled carbon nanotubes into male mice can cause reversible testis damage without affecting fertility. Nanotubes accumulated in the testes, generated oxidative stress and decreased the thickness of the seminiferous epithelium in the testis at day 15, but the damage was repaired at 60 and 90 days. The quantity, quality and integrity of the sperm and the levels of three major sex hormones were not significantly affected throughout the 90-day period. The fertility of treated male mice was unaffected; the pregnancy rate and delivery success of female mice that mated with the treated male mice did not differ from those that mated with untreated male mice.
Male mice treated with water-soluble multiwalled carbon nanotubes show reversible testis damage with no effect on fertility.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
