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Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials
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Journal Article
Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials
2021
Overview
We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of
Acinetobacter baumannii
and established that the bacterial capsule is the receptor for these phages. Phage-resistant mutants harboured loss-of-function mutations in genes responsible for capsule biosynthesis, resulting in capsule loss and disruption of phage adsorption. The phage-resistant strains were resensitized to human complement, beta-lactam antibiotics and alternative phages and exhibited diminished fitness in vivo. Using a mouse model of
A. baumannii
infection, we showed that phage therapy was effective.
The authors characterize two phages against
Acinetobacter baumannii
, both in vitro and in vivo.
A. baumannii
strains develop resistance against both phages, but are in turn resensitized to different antimicrobial compounds.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 14/63
/ 38
/ 42
/ 42/44
/ 45
/ 45/22
/ 45/23
/ 45/77
/ Acinetobacter baumannii - drug effects
/ Acinetobacter baumannii - genetics
/ Acinetobacter baumannii - virology
/ Acinetobacter Infections - microbiology
/ Acinetobacter Infections - therapy
/ Animals
/ Anti-Bacterial Agents - pharmacology
/ Bacterial Capsules - virology
/ beta-Lactamase Inhibitors - pharmacology
/ Biomedical and Life Sciences
/ Complement System Proteins - pharmacology
/ Female
/ Genes
/ Humans
/ Mice
/ Mutation
/ Phages
/ Virology
