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WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition

by Eng, Charis , Ni, Ying , Liu, Jing , Kishikawa, Takahiro , Leach, Brandie , Zhang, Jinfang , Panch, Nivedita , Wei, Wenyi , Lee, Yu-Ru , Yehia, Lamis , Pandolfi, Pier Paolo

in 1-Phosphatidylinositol 3-kinase / Adult / Age / Animal models / Animals / Cancer / Colon / Colorectal cancer / Consortia / Cowden syndrome / CRISPR / Disease Models, Animal / Female / Gain of Function Mutation / Genes / Genetic Predisposition to Disease / Genetic Variation / Genomes / Germ-Line Mutation / Hamartoma Syndrome, Multiple - genetics / Humans / Hypotheses / Kinases / Male / Mice / Mice, Mutant Strains / Mutation / Neoplasia / Pedigree / Phenotypes / Phosphatase / Prospective Studies / Proteins / PTEN Phosphohydrolase - genetics / PTEN protein / Tensin / Ubiquitin / Ubiquitin-protein ligase / Ubiquitin-Protein Ligases - genetics

2020

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WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition

by Eng, Charis , Ni, Ying , Liu, Jing , Kishikawa, Takahiro , Leach, Brandie , Zhang, Jinfang , Panch, Nivedita , Wei, Wenyi , Lee, Yu-Ru , Yehia, Lamis , Pandolfi, Pier Paolo

2020

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WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition

by Eng, Charis , Ni, Ying , Liu, Jing , Kishikawa, Takahiro , Leach, Brandie , Zhang, Jinfang , Panch, Nivedita , Wei, Wenyi , Lee, Yu-Ru , Yehia, Lamis , Pandolfi, Pier Paolo

2020

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Journal Article

WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition

Eng, Charis,

Ni, Ying,

Liu, Jing,

Kishikawa, Takahiro,

Leach, Brandie,

Zhang, Jinfang,

Panch, Nivedita,

Wei, Wenyi,

Lee, Yu-Ru,

Yehia, Lamis,

Pandolfi, Pier Paolo

2020

Overview

PTEN defects underlie disorders with several heritable neoplasms, including the Cowden syndrome, but many patients with these syndromes do not carry PTEN mutations. Some patients with hamartomatous inherited tumors have enhanced function of the WWP1 ubiquitin ligase that increases PTEN degradation and fosters tumor-promoting PI3K activity.

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Publisher

Massachusetts Medical Society

Subject

1-Phosphatidylinositol 3-kinase

/ Adult

/ Age

/ Animal models

/ Animals

/ Cancer

/ Colon