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A meta-analysis of the effect of binge drinking on the oral microbiome and its relation to Alzheimer’s disease
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A meta-analysis of the effect of binge drinking on the oral microbiome and its relation to Alzheimer’s disease
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Journal Article
A meta-analysis of the effect of binge drinking on the oral microbiome and its relation to Alzheimer’s disease
2020
Overview
The diversity of bacterial species in the oral cavity makes it a key site for research. The close proximity of the oral cavity to the brain and the blood brain barrier enhances the interest to study this site. Changes in the oral microbiome are linked to multiple systemic diseases. Alcohol is shown to cause a shift in the microbiome composition. This change, particularly in the oral cavity, may lead to neurological diseases. Alzheimer’s disease (AD) is a common neurodegenerative disorder that may cause irreversible memory loss. This study uses the meta-analysis method to establish the link between binge drinking, the oral microbiome and AD. The QIAGEN Ingenuity Pathway Analysis (IPA) shows that high levels of ethanol in binge drinkers cause a shift in the microbiome that leads to the development of AD through the activation of eIF2, regulation of eIF4 and p70S6K signaling, and mTOR signaling pathways. The pathways associated with both binge drinkers and AD are also analyzed. This study provides a foundation that shows how binge drinking and the oral microbiome dysbiosis lead to permeability changes in the blood brain barrier (BBB), which may eventually result in the pathogenesis of AD.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 631/378
/ Alzheimer Disease - epidemiology
/ Alzheimer Disease - etiology
/ Alzheimer Disease - metabolism
/ Binge Drinking - complications
/ Binge Drinking - epidemiology
/ Blood-Brain Barrier - metabolism
/ Ethanol
/ Eukaryotic Initiation Factor-2 - metabolism
/ Eukaryotic Initiation Factor-4F - metabolism
/ Humanities and Social Sciences
/ Humans
/ Ribosomal Protein S6 Kinases, 70-kDa - metabolism
/ Science
