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GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment
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GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment
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Journal Article
GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment
2016
Overview
Some polypeptide N-acetyl-galactosaminyltransferases (GALNTs) are associated with cancer, but their function in organ-specific metastasis remains unclear. Here, we report that GALNT14 promotes breast cancer metastasis to the lung by enhancing the initiation of metastatic colonies as well as their subsequent growth into overt metastases. Our results suggest that GALNT14 augments the self-renewal properties of breast cancer cells (BCCs). Furthermore, GALNT14 overcomes the inhibitory effect of lung-derived bone morphogenetic proteins (BMPs) on self-renewal and therefore facilitates metastasis initiation within the lung microenvironment. In addition, GALNT14 supports continuous growth of BCCs in the lung by not only inducing macrophage infiltration but also exploiting macrophage-derived fibroblast growth factors (FGFs). Finally, we identify KRAS-PI3K-c-JUN signalling as an upstream pathway that accounts for the elevated expression of
GALNT14
in lung-metastatic BCCs. Collectively, our findings uncover an unprecedented role for GALNT14 in the pulmonary metastasis of breast cancer and elucidate the underlying molecular mechanisms.
Polypeptide N-acetyl-galactosaminyltransferases (GALNTs) are associated with cancer, but their function in organ-specific metastasis is unclear. Here the authors show that GALNT14 promotes breast cancer metastasis to the lung by enhancing the initiation of metastatic colonies and subsequent growth.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/91
/ 64/60
/ 96/1
/ Animals
/ Bone Morphogenetic Protein Receptors - antagonists & inhibitors
/ Breast Neoplasms - metabolism
/ Breast Neoplasms - pathology
/ Datasets
/ Female
/ Gene Expression Regulation, Neoplastic - drug effects
/ Guanine Nucleotide Exchange Factors
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Mutation
/ N-Acetylgalactosaminyltransferases - genetics
/ N-Acetylgalactosaminyltransferases - metabolism
/ Neoplasms, Experimental - pathology
/ Polypeptide N-acetylgalactosaminyltransferase
/ Proteins
/ Receptors, Notch - antagonists & inhibitors
/ Receptors, Transforming Growth Factor beta - antagonists & inhibitors
/ Science
/ Tumors
