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thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels
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thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels
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thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels
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Journal Article
thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels
2011
Overview
The exceptionally high temperature sensitivity of certain transient receptor potential (TRP) family ion channels is the molecular basis of hot and cold sensation in sensory neurons. The laws of thermodynamics dictate that opening of these specialized TRP channels must involve an unusually large conformational standard-state enthalpy, ΔHo: positive ΔHo for heat-activated and negative ΔHo for cold-activated TRPs. However, the molecular source of such high-enthalpy changes has eluded neurobiologists and biophysicists. Here we offer a general, unifying mechanism for both hot and cold activation that recalls long-appreciated principles of protein folding. We suggest that TRP channel gating is accompanied by large changes in molar heat capacity, ΔCP. This postulate, along with the laws of thermodynamics and independent of mechanistic detail, leads to the conclusion that hot- and cold-sensing TRPs operate by identical conformational changes.
