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The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1

by Ferré, Elise M.N. , Quezado, Martha M. , Lee, Chyi-chia R. , Monserrat-Garcia, Maria Teresa , Kuehn, Hye Sun , Deljookorani, Shiva , Kumar, Dhaneshwar , Holland, Steven M. , Rastegar, Andre , Ekwall, Olov , Oikonomou, Vasileios , Olbrich, Peter , Rosen, Lindsey B. , Winer, Karen K. , Heller, Theo , Hero, Matti , Stoddard, Jennifer , Warner, Blake M. , Lionakis, Michail S. , Afzali, Behdad , Seppänen, Mikko R. J. , Hadjiyannis, Yannis , Anderson, Mark S. , Barber, Princess , Pechacek, Joseph , Ghosh, Rajarshi , Besnard, Marine , Lundberg, Vanja , de Jesus, Adriana A. , Suffredini, Anthony F. , Guillonneau, Carole , Cheng, Aristine , Smith, Grace , Kong, Heidi H. , DiMaggio, Tom , Kleiner, David E. , Walkiewicz, Magdalena , Gomez-Gila, Ana Lucia , Webb, Taura , Klemetti, Paula , Seifert, Bryce A. , Davis, Jeremy L. , Swidergall, Marc , Dos Santos Dias, Lucas , Neth, Olaf , Snarr, Brendan D. , Castelo-Soccio, Leslie , Moutsopoulos, Niki M. , Break, Timothy J. , Valverde-Fernandez, Justo , Laakso, Saila , Constantine, Gregory M. , Martin, Daniel , Rosenzweig, Sergio D. , Lohi, Jouko , Pittaluga, Stefania , Garcia Rojas, Angela , Notarangelo, Luigi D. , Alejo,

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2024

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2024

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2024

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Journal Article

The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1

Ferré, Elise M.N.,

Quezado, Martha M.,

Lee, Chyi-chia R.,

Monserrat-Garcia, Maria Teresa,

Kuehn, Hye Sun,

Deljookorani, Shiva,

Kumar, Dhaneshwar,

Holland, Steven M.,

Rastegar, Andre,

Ekwall, Olov,

Oikonomou, Vasileios,

Olbrich, Peter,

Rosen, Lindsey B.,

Winer, Karen K.,

Heller, Theo,

Hero, Matti,

Stoddard, Jennifer,

Warner, Blake M.,

Lionakis, Michail S.,

Afzali, Behdad,

Seppänen, Mikko R. J.,

Hadjiyannis, Yannis,

Anderson, Mark S.,

Barber, Princess,

Pechacek, Joseph,

Ghosh, Rajarshi,

Besnard, Marine,

Lundberg, Vanja,

de Jesus, Adriana A.,

Suffredini, Anthony F.,

Guillonneau, Carole,

Cheng, Aristine,

Smith, Grace,

Kong, Heidi H.,

DiMaggio, Tom,

Kleiner, David E.,

Walkiewicz, Magdalena,

Gomez-Gila, Ana Lucia,

Webb, Taura,

Klemetti, Paula,

Seifert, Bryce A.,

Davis, Jeremy L.,

Swidergall, Marc,

Dos Santos Dias, Lucas,

Neth, Olaf,

Snarr, Brendan D.,

Castelo-Soccio, Leslie,

Moutsopoulos, Niki M.,

Break, Timothy J.,

Valverde-Fernandez, Justo,

Laakso, Saila,

Constantine, Gregory M.,

Martin, Daniel,

Rosenzweig, Sergio D.,

Lohi, Jouko,

Pittaluga, Stefania,

Garcia Rojas, Angela,

Notarangelo, Luigi D.,

Alejo,

2024

Overview

In this study, interferon-γ was found to play a large role in the pathogenesis of APS-1. Results were confirmed in studies in animals and led to a trial of ruxolitinib in five patients, who had dramatic responses.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adolescent Medicine

/ Adrenal Disease

/ Adult

/ AIRE Protein

/ AIRE Protein - deficiency

/ AIRE Protein - genetics