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Sperm derived H2AK119ub1 is required for embryonic development in Xenopus laevis
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Sperm derived H2AK119ub1 is required for embryonic development in Xenopus laevis
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Journal Article
Sperm derived H2AK119ub1 is required for embryonic development in Xenopus laevis
2025
Overview
Ubiquitylation of H2A (H2AK119ub1) by the polycomb repressive complexe-1 plays a key role in the initiation of facultative heterochromatin formation in somatic cells. Here we evaluate the contribution of sperm derived H2AK119ub1 to embryo development. In
Xenopus laevis
we found that H2AK119ub1 is present during spermiogenesis and into early embryonic development, highlighting its credential for a role in the transmission of epigenetic information from the sperm to the embryo. In vitro treatment of sperm with USP21, a H2AK119ub1 deubiquitylase, just prior to injection to egg, results in developmental defects associated with gene upregulation. Sperm H2AK119ub1 editing disrupts egg factor mediated paternal chromatin remodelling processes. It leads to post-replication accumulation of H2AK119ub1 on repeat element of the genome instead of CpG islands. This shift in post-replication H2AK119ub1 distribution triggered by sperm epigenome editing entails a loss of H2AK119ub1 from genes misregulated in embryos derived from USP21 treated sperm. We conclude that sperm derived H2AK119ub1 instructs egg factor mediated epigenetic remodelling of paternal chromatin and is required for embryonic development.
Sperm chromatin retains post-translationally modified histones whose function, after delivery to egg, is unclear. Using H2AK119Ub1 edited sperm the authors show that a sperm derived epigenetic cue is necessary for frog embryo development.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/15
/ 38/22
/ 38/23
/ 38/39
/ 38/91
/ 45
/ 45/15
/ 45/29
/ 631/136
/ Animals
/ Chromatin Assembly and Disassembly
/ Editing
/ Embryo, Nonmammalian - metabolism
/ Embryonic Development - genetics
/ Embryos
/ Female
/ Gene Expression Regulation, Developmental
/ Histones
/ Humanities and Social Sciences
/ Male
/ Science
/ Sperm
