Journal Article

Imported strongyloidiasis: Data from 1245 cases registered in the +REDIVI Spanish Collaborative Network (2009-2017)

Salvador, Fernando, Sulleiro, Elena, Goikoetxea, Josune, Serre-Delcor, Núria, Herrero-Martínez, Juan María, Chamorro-Tojeiro, Sandra, Treviño, Begoña, Sánchez-Montalvá, Adrián, Torrús, Diego, López-Vélez, Rogelio, Pérez-Molina, José Antonio, Molina, Israel, Rodríguez-Guardado, Azucena, Zubero, Zuriñe, Velasco, María

2019

Overview

Imported strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported strongyloidiasis in Spain. This is an observational retrospective study that included all patients diagnosed of strongyloidiasis registered in the +REDIVI Collaborative Network from 2009 to 2017. Demographic, epidemiological and clinical information was collected from the +REDIVI database, and extra information regarding microbiological techniques, treatment and follow-up was requested to participant centers. Overall, 1245 cases were included. Most of them were immigrants (66.9%), and South America was the most frequent area of origin. Detection of larvae in stool samples was observed in 21.9% of the patients, and serological tests allowed making the diagnosis in the rest of the cases. Eosinophilia was present in 82.2% of cases. Treatment with ivermectin (compared with albendazole) was the most strongly associated factor to achieve the cure (OR 2.34). Given the long latency of the infection and the risk of developing a severe presentation, screening of S. stercoralis infection should be mandatory in patients coming from or had traveling to endemic areas, especially in those with immunosuppressant conditions.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adolescent / Adult / Aged / Aged, 80 and over / Albendazole / Albendazole - therapeutic use / Animals / Anthelmintics - therapeutic use / Biology and Life Sciences / Blood diseases / Care and treatment / Child / Child, Preschool / Collaboration / Country of birth / Demographics / Detection / Development and progression / Diagnosis / Drug dosages / Emigrants and Immigrants - statistics & numerical data / Enzymes / Eosinophilia / Eosinophilia - etiology / Epidemiology / Female / Health risks / Hospitals / Humans / Immigrants / Immunosuppressive agents / Infant / Infections / Ivermectin / Ivermectin - therapeutic use / Larvae / Latency / Male / Medical research / Medicine and Health Sciences / Microbiology / Middle Aged / Observational studies / Parasites / Parasitic diseases / Patients / People and places / Public health / Retrospective Studies / Risk factors / Serological tests / South America / Spain - epidemiology / Strongyloides stercoralis - drug effects / Strongyloides stercoralis - isolation & purification / Strongyloides stercoralis - physiology / Strongyloidiasis / Strongyloidiasis - complications / Strongyloidiasis - diagnosis / Strongyloidiasis - epidemiology / Strongyloidiasis - parasitology / Travel / Tropical diseases / Young Adult