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Facile syntheses of conjugated polymers for photothermal tumour therapy
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Facile syntheses of conjugated polymers for photothermal tumour therapy
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Journal Article
Facile syntheses of conjugated polymers for photothermal tumour therapy
2019
Overview
Development of photothermal materials which are able to harness sunlight and convert it to thermal energy seems attractive. Besides carbon-based nanomaterials, conjugated polymers are emerging promising photothermal materials but their facile syntheses remain challenging. In this work, by modification of a CBT-Cys click condensation reaction and rational design of the starting materials, we facilely synthesize conjugated polymers poly-2-phenyl-benzobisthiazole (PPBBT) and its dihexyl derivative with good photothermal properties. Under the irradiation of either sunlight-mimicking Xe light or near-infrared laser, we verify that PPBBT has comparable photothermal heating-up speed to that of star material single-wall carbon nanotube. Moreover, PPBBT is used to fabricate water-soluble NP
PPBBT
nanoparticles which maintain excellent photothermal properties in vitro and photothermal therapy effect on the tumours exposed to laser irradiation. We envision that our synthetic method provides a facile approach to fabricate conjugated polymers for more promising applications in biomedicine or photovoltaics in the near future.
Conjugated polymers are of interest for photothermal applications; however, synthesis of these polymers can be complex. Here, the authors report on a facile synthesis method that uses a modified CBT-Cys click reaction to make conjugated polymers and test these polymers for photothermal therapy applications.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/51
/ 14/19
/ 140/131
/ 140/146
/ 140/58
/ 147/143
/ 64/60
/ Animals
/ Cell Line, Tumor - transplantation
/ Combined Modality Therapy - methods
/ Female
/ Humanities and Social Sciences
/ Humans
/ Hyperthermia, Induced - instrumentation
/ Hyperthermia, Induced - methods
/ Lasers
/ Mice
/ Microscopy, Electron, Transmission
/ Mimicry
/ Nanoparticles - administration & dosage
/ Nanoparticles - radiation effects
/ Nanoparticles - ultrastructure
/ Polymers
/ Polymers - administration & dosage
/ Polymers - radiation effects
/ Science
/ Single wall carbon nanotubes
/ Sunlight
/ Theranostic Nanomedicine - methods
/ Therapy
/ Tumors
