Asset Details
Do you wish to reserve the book?
Nanohole-boosted electron transport between nanomaterials and bacteria as a concept for nano–bio interactions
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Nanohole-boosted electron transport between nanomaterials and bacteria as a concept for nano–bio interactions
Do you wish to request the book?
Nanohole-boosted electron transport between nanomaterials and bacteria as a concept for nano–bio interactions
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Nanohole-boosted electron transport between nanomaterials and bacteria as a concept for nano–bio interactions
2021
Overview
Biofilms contribute to bacterial infection and drug resistance and are a serious threat to global human health. Antibacterial nanomaterials have attracted considerable attention, but the inhibition of biofilms remains a major challenge. Herein, we propose a nanohole-boosted electron transport (NBET) antibiofilm concept. Unlike known antibacterial mechanisms (e.g., reactive oxygen species production and cell membrane damage), nanoholes with atomic vacancies and biofilms serve as electronic donors and receptors, respectively, and thus boost the high electron transport capacity between nanomaterials and biofilms. Electron transport effectively destroys the critical components (proteins, intercellularly adhered polysaccharides and extracellular DNA) of biofilms, and the nanoholes also significantly downregulate the expression of genes related to biofilm formation. The anti-infection capacity is thoroughly verified both in vitro (human cells) and in vivo (rat ocular and mouse intestinal infection models), and the nanohole-enabled nanomaterials are found to be highly biocompatible. Importantly, compared with typical antibiotics, nanomaterials are nonresistant and thereby exhibit high potential for use in various applications. As a proof-of-principle demonstration, these findings hold promise for the use of NBET in treatments for pathogenic bacterial infection and antibiotic drug resistance.
Nanomaterials have attracted attention as antibacterial agents and have several modes of action. Here, the authors report on 2D transition metal disulphide nanosheets with hole boosted electron donation/withdrawal for enhanced antibacterial and biofilm activity caused by electron damage.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/31
/ 14/3
/ 147/28
/ 38/47
/ 64/86
/ Animals
/ Anti-Bacterial Agents - administration & dosage
/ Bacteria
/ Biofilms
/ Damage
/ DNA
/ Electron Transport - drug effects
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Nanostructures - administration & dosage
/ Rats
/ Science
/ Staphylococcal Infections - drug therapy
/ Staphylococcal Infections - microbiology
/ Staphylococcus aureus - drug effects
