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In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy
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In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy
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Journal Article
In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy
2020
Overview
Vesicular photothermal therapy agents (PTAs) are highly desirable in photothermal therapy (PTT) for their excellent light-harvesting ability and versatile hollow compartments. However, up to now, the reported vesicular PTAs are generally self-assembled from small molecules like liposomes, and polymer vesicles have seldom been used as PTAs due to the unsatisfactory photothermal conversion efficiency resulting from the irregular packing of chromophores in the vesicle membranes. Here we report a nano-sized polymer vesicle from hyperbranched polyporphyrins with favorable photothermal stability and extraordinarily high photothermal efficiency (44.1%), showing great potential in imaging-guided PTT for tumors through in vitro and in vivo experiments. These excellent properties are attributed to the in situ supramolecular polymerization of porphyrin units inside the vesicle membrane into well-organized 1D monofilaments driven by π–π stacking. We believe the supramolecular polymerization-enhanced self-assembly process reported here will shed a new light on the design of supramolecular materials with new structures and functions.
Photothermal therapy (PTT) has recently emerged as a promising approach for cancer therapy. Here, the authors report a hyperbranched polymer vesicle with favorable photothermal stability and high photothermal efficiency for PTT through a supramolecular polymerization-enhanced self-assembly strategy.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14
/ 59
/ 64
/ 64/60
/ Animals
/ Cell Survival - drug effects
/ Female
/ Humanities and Social Sciences
/ Humans
/ Hydrophobic and Hydrophilic Interactions
/ Hyperthermia, Induced - methods
/ Mice
/ Microscopy, Electron, Scanning
/ Molecular Dynamics Simulation
/ Nanoparticles - therapeutic use
/ Nanoparticles - ultrastructure
/ Polymers
/ Polymers - chemical synthesis
/ Porphyrins - chemical synthesis
/ Porphyrins - pharmacokinetics
/ Porphyrins - therapeutic use
/ Rats
/ Science
/ Therapy
/ Transplantation, Heterologous
/ Tumors
/ Vesicles
