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A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection
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A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection
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Journal Article
A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection
2019
Overview
Candida albicans
can switch from commensal to pathogenic mode, causing mucosal or disseminated candidiasis. The host relies on pattern-recognition receptors including Toll-like receptors (TLRs) and C-type lectin receptors (CLRs) to sense invading fungal pathogens and launch immune defense mechanisms. However, the complex interplay between fungus and host innate immunity remains incompletely understood. Here we report that
C
.
albicans
upregulates expression of a small secreted cysteine-rich protein Sel1 upon encountering limited nitrogen and abundant serum. Sel1 activates NF-κB and MAPK signaling pathways, leading to expression of proinflammatory cytokines and chemokines. Comprehensive genetic and biochemical analyses reveal both TLR2 and TLR4 are required for the recognition of Sel1. Further,
SEL1
-deficient
C
.
albicans
display an impaired immune response in vivo, causing increased morbidity and mortality in a bloodstream infection model. We identify a critical component in the Candida-host interaction that opens a new avenue to tackle Candida infection and inflammation.
The interplay between fungal pathogens and the innate immune system remains incompletely understood. Here, Wang et al. show that a small protein secreted by
Candida albicans
induces a TLR2- and TLR4-mediated inflammatory response in a mouse infection model.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/95
/ 38
/ 38/109
/ 38/77
/ 38/88
/ 38/90
/ Animals
/ Candida
/ Candida albicans - pathogenicity
/ Carrier Proteins - immunology
/ Carrier Proteins - metabolism
/ Fungi
/ Humanities and Social Sciences
/ Immunity
/ LIM Domain Proteins - genetics
/ LIM Domain Proteins - immunology
/ LIM Domain Proteins - metabolism
/ Male
/ Mice
/ Mitogen-Activated Protein Kinase Kinases - metabolism
/ Mucosa
/ Proteins
/ Science
/ Toll-Like Receptor 2 - genetics
/ Toll-Like Receptor 2 - immunology
/ Toll-Like Receptor 2 - metabolism
/ Toll-Like Receptor 4 - genetics
/ Toll-Like Receptor 4 - immunology
