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Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
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Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
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Journal Article
Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
2021
Overview
Brown adipocytes share the same developmental origin with skeletal muscle. Here we find that a brown adipocyte-to-myocyte remodeling also exists in mature brown adipocytes, and is induced by prolonged high fat diet (HFD) feeding, leading to brown fat dysfunction. This process is regulated by the interaction of epigenetic pathways involving histone and DNA methylation. In mature brown adipocytes, the histone demethylase UTX maintains persistent demethylation of the repressive mark H3K27me3 at
Prdm16
promoter, leading to high
Prdm16
expression. PRDM16 then recruits DNA methyltransferase DNMT1 to
Myod1
promoter, causing
Myod1
promoter hypermethylation and suppressing its expression. The interaction between PRDM16 and DNMT1 coordinately serves to maintain brown adipocyte identity while repressing myogenic remodeling in mature brown adipocytes, thus promoting their active brown adipocyte thermogenic function. Suppressing this interaction by HFD feeding induces brown adipocyte-to-myocyte remodeling, which limits brown adipocyte thermogenic capacity and compromises diet-induced thermogenesis, leading to the development of obesity.
Brown adipocytes contribute to energy balance, and adipocyte development and brown adipocyte thermogenesis are in part regulated by epigenetic modifications. Here the authors report that the histone demethylase Utx maintains brown adipocyte identity via demethylation of PRDM16, which in turn represses myogenic remodelling via DNMT1-mediated Myod1 promoter hypermethylation in mice.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
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/ Adipocytes, Brown - metabolism
/ Adipocytes, Brown - pathology
/ Adipose Tissue, Brown - metabolism
/ Adipose Tissue, Brown - pathology
/ Animals
/ Diet
/ Diet, High-Fat - adverse effects
/ DNA
/ DNA (Cytosine-5-)-Methyltransferase 1 - deficiency
/ DNA (Cytosine-5-)-Methyltransferase 1 - metabolism
/ DNA Methyltransferase 3A - deficiency
/ DNA Methyltransferase 3A - metabolism
/ DNA-Binding Proteins - metabolism
/ Histone Demethylases - deficiency
/ Histone Demethylases - metabolism
/ Histones
/ Humanities and Social Sciences
/ Mice
/ Muscle Development - genetics
/ Muscles
/ Myocytes
/ Myogenic Regulatory Factor 5 - metabolism
/ Science
